ENSAPLP00000026062 protein (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSAPLP00000026062

Uncharacterized protein. (199 aa)

Predicted Functional Partners:

SKP1

0.703

ENSAPLP00000028245

0.680

U3I833_ANAPP

0.594

ARID5B

0.594

ENSAPLP00000026892

0.594

HIST2H3PS2

0.594

ENSAPLP00000030836

0.594

SUV39H2

0.542

KDM3A

0.523

MYD88

0.514

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID5B	ENSAPLP00000026062	ENSAPLP00000010677	ENSAPLP00000026062	AT-rich interaction domain 5B.	Uncharacterized protein.	0.594
ARID5B	ENSAPLP00000028245	ENSAPLP00000010677	ENSAPLP00000028245	AT-rich interaction domain 5B.	Uncharacterized protein.	0.418
ENSAPLP00000026062	ARID5B	ENSAPLP00000026062	ENSAPLP00000010677	Uncharacterized protein.	AT-rich interaction domain 5B.	0.594
ENSAPLP00000026062	ENSAPLP00000026892	ENSAPLP00000026062	ENSAPLP00000026892	Uncharacterized protein.	annotation not available	0.594
ENSAPLP00000026062	ENSAPLP00000028245	ENSAPLP00000026062	ENSAPLP00000028245	Uncharacterized protein.	Uncharacterized protein.	0.680
ENSAPLP00000026062	ENSAPLP00000030836	ENSAPLP00000026062	ENSAPLP00000030836	Uncharacterized protein.	Histone domain-containing protein.	0.594
ENSAPLP00000026062	HIST2H3PS2	ENSAPLP00000026062	ENSAPLP00000027122	Uncharacterized protein.	Histone cluster 2 H3 pseudogene 2.	0.594
ENSAPLP00000026062	KDM3A	ENSAPLP00000026062	ENSAPLP00000003798	Uncharacterized protein.	Lysine demethylase 3A.	0.523
ENSAPLP00000026062	MYD88	ENSAPLP00000026062	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.514
ENSAPLP00000026062	SKP1	ENSAPLP00000026062	ENSAPLP00000014996	Uncharacterized protein.	S-phase kinase associated protein 1; Belongs to the SKP1 family.	0.703
ENSAPLP00000026062	SUV39H2	ENSAPLP00000026062	ENSAPLP00000005720	Uncharacterized protein.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.542
ENSAPLP00000026062	U3I833_ANAPP	ENSAPLP00000026062	ENSAPLP00000003404	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.594
ENSAPLP00000026892	ENSAPLP00000026062	ENSAPLP00000026892	ENSAPLP00000026062	annotation not available	Uncharacterized protein.	0.594
ENSAPLP00000026892	ENSAPLP00000028245	ENSAPLP00000026892	ENSAPLP00000028245	annotation not available	Uncharacterized protein.	0.893
ENSAPLP00000026892	SUV39H2	ENSAPLP00000026892	ENSAPLP00000005720	annotation not available	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.794
ENSAPLP00000028245	ARID5B	ENSAPLP00000028245	ENSAPLP00000010677	Uncharacterized protein.	AT-rich interaction domain 5B.	0.418
ENSAPLP00000028245	ENSAPLP00000026062	ENSAPLP00000028245	ENSAPLP00000026062	Uncharacterized protein.	Uncharacterized protein.	0.680
ENSAPLP00000028245	ENSAPLP00000026892	ENSAPLP00000028245	ENSAPLP00000026892	Uncharacterized protein.	annotation not available	0.893
ENSAPLP00000028245	ENSAPLP00000030836	ENSAPLP00000028245	ENSAPLP00000030836	Uncharacterized protein.	Histone domain-containing protein.	0.893
ENSAPLP00000028245	HIST2H3PS2	ENSAPLP00000028245	ENSAPLP00000027122	Uncharacterized protein.	Histone cluster 2 H3 pseudogene 2.	0.893

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.531

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

4 of 146

1.62

0.85

0.0181

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019888

Protein phosphatase regulator activity

5 of 61

2.09

2.89

1.02e-06

GO:0030234

Enzyme regulator activity

6 of 929

0.99

0.67

0.0100

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005963

Magnesium-dependent protein serine/threonine phosphatase complex

5 of 21

2.56

4.37

3.78e-09

GO:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.84

6.22e-08

GO:0140535

Intracellular protein-containing complex

6 of 610

1.17

1.12

0.00026

GO:1902494

Catalytic complex

6 of 1194

0.88

0.6

0.0104

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17552

Protein phosphatase type 2A complex, and ERKs are inactivated

7 of 16

2.82

7.49

4.28e-15

CL:17555

Protein phosphatase type 2A complex, and Serine/Threonine protein phosphatase PP2A-like

5 of 10

2.88

5.46

6.04e-11

CL:17557

Protein phosphatase 2A regulatory subunit PR55, and Serine/Threonine protein phosphatase PP2A-like

2 of 5

2.78

1.38

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla04114

Oocyte meiosis

6 of 81

2.05

3.94

1.29e-09

apla03015

mRNA surveillance pathway

5 of 45

2.22

3.91

7.57e-09

apla04261

Adrenergic signaling in cardiomyocytes

5 of 81

1.97

3.17

8.21e-08

apla04350

TGF-beta signaling pathway

3 of 72

1.8

1.54

0.00059

apla04136

Autophagy - other

2 of 19

2.2

1.35

0.0028

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389513

CTLA4 inhibitory signaling

6 of 23

2.6

5.58

1.24e-11

MAP-196299

Beta-catenin phosphorylation cascade

5 of 12

2.8

5.15

2.07e-10

MAP-195253

Degradation of beta-catenin by the destruction complex

6 of 44

2.31

4.68

2.07e-10

MAP-388841

Costimulation by the CD28 family

6 of 72

2.1

3.99

1.66e-09

MAP-68882

Mitotic Anaphase

7 of 210

1.7

3.0

5.15e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.68

1.27e-07

GOCC:0008287

Protein serine/threonine phosphatase complex

5 of 44

2.23

3.4

1.27e-07

GOCC:1902494

Catalytic complex

9 of 1192

1.06

1.23

9.68e-07

GOCC:0032991

Protein-containing complex

10 of 3780

0.6

0.48

0.0010

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01603

Protein phosphatase 2A regulatory B subunit (B56 family)

3 of 4

3.05

2.66

1.47e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002554

Protein phosphatase 2A, regulatory B subunit, B56

3 of 4

3.05

2.39

4.57e-05

IPR047129

Serine/Threonine protein phosphatase PP2A-like

2 of 4

2.88

0.97

0.0176

IPR011989

Armadillo-like helical

4 of 192

1.5

0.83

0.0176

IPR006186

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

2 of 12

2.4

0.75

0.0438

IPR016024

Armadillo-type fold

4 of 280

1.33

0.65

0.0380

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00156

Protein phosphatase 2A homologues, catalytic domain.

2 of 11

2.44

0.9

0.0225

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About