ENSAPLP00000026926 protein (Anas platyrhynchos)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ENSAPLP00000026926

Uncharacterized protein. (611 aa)

Predicted Functional Partners:

U3IMS8_ANAPP

0.900

SPATA2

0.900

SPATA2L

0.900

CYLD

0.900

SHROOM1

0.458

ENSAPLP00000018291

0.446

ENSAPLP00000020532

0.446

ENSAPLP00000021030

0.446

ENSAPLP00000028965

0.446

ENSAPLP00000030249

0.446

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYLD	ENSAPLP00000026926	ENSAPLP00000027424	ENSAPLP00000026926	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.900
CYLD	SPATA2	ENSAPLP00000027424	ENSAPLP00000014477	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Spermatogenesis associated 2.	0.960
CYLD	SPATA2L	ENSAPLP00000027424	ENSAPLP00000023526	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Spermatogenesis associated 2 like.	0.908
CYLD	U3IMS8_ANAPP	ENSAPLP00000027424	ENSAPLP00000008551	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.903
ENSAPLP00000018291	ENSAPLP00000026926	ENSAPLP00000018291	ENSAPLP00000026926	PPIase cyclophilin-type domain-containing protein.	Uncharacterized protein.	0.446
ENSAPLP00000020532	ENSAPLP00000021030	ENSAPLP00000020532	ENSAPLP00000021030	RanBD1 domain-containing protein.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.935
ENSAPLP00000020532	ENSAPLP00000026926	ENSAPLP00000020532	ENSAPLP00000026926	RanBD1 domain-containing protein.	Uncharacterized protein.	0.446
ENSAPLP00000020532	ENSAPLP00000028965	ENSAPLP00000020532	ENSAPLP00000028965	RanBD1 domain-containing protein.	RanBD1 domain-containing protein.	0.938
ENSAPLP00000020532	ENSAPLP00000030249	ENSAPLP00000020532	ENSAPLP00000030249	RanBD1 domain-containing protein.	RanBD1 domain-containing protein.	0.402
ENSAPLP00000021030	ENSAPLP00000020532	ENSAPLP00000021030	ENSAPLP00000020532	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	RanBD1 domain-containing protein.	0.935
ENSAPLP00000021030	ENSAPLP00000026926	ENSAPLP00000021030	ENSAPLP00000026926	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	Uncharacterized protein.	0.446
ENSAPLP00000021030	ENSAPLP00000028965	ENSAPLP00000021030	ENSAPLP00000028965	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	RanBD1 domain-containing protein.	0.794
ENSAPLP00000021030	ENSAPLP00000030249	ENSAPLP00000021030	ENSAPLP00000030249	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	RanBD1 domain-containing protein.	0.935
ENSAPLP00000026926	CYLD	ENSAPLP00000026926	ENSAPLP00000027424	Uncharacterized protein.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.900
ENSAPLP00000026926	ENSAPLP00000018291	ENSAPLP00000026926	ENSAPLP00000018291	Uncharacterized protein.	PPIase cyclophilin-type domain-containing protein.	0.446
ENSAPLP00000026926	ENSAPLP00000020532	ENSAPLP00000026926	ENSAPLP00000020532	Uncharacterized protein.	RanBD1 domain-containing protein.	0.446
ENSAPLP00000026926	ENSAPLP00000021030	ENSAPLP00000026926	ENSAPLP00000021030	Uncharacterized protein.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.446
ENSAPLP00000026926	ENSAPLP00000028965	ENSAPLP00000026926	ENSAPLP00000028965	Uncharacterized protein.	RanBD1 domain-containing protein.	0.446
ENSAPLP00000026926	ENSAPLP00000030249	ENSAPLP00000026926	ENSAPLP00000030249	Uncharacterized protein.	RanBD1 domain-containing protein.	0.446
ENSAPLP00000026926	SHROOM1	ENSAPLP00000026926	ENSAPLP00000021604	Uncharacterized protein.	Uncharacterized protein.	0.458

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.767

expected number of edges:

4

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

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