THOC1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

THOC1

THO complex 1. (664 aa)

Predicted Functional Partners:

THOC7

0.999

THOC2

0.999

THOC3

0.999

THOC5

0.996

ENSAPLP00000029486

0.966

ZC3H13

0.935

ENSAPLP00000029053

0.926

CHTOP

0.836

POLDIP3

0.834

ENSAPLP00000020998

0.786

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHTOP	ENSAPLP00000029053	ENSAPLP00000009643	ENSAPLP00000029053	Chromatin target of PRMT1.	RRM domain-containing protein.	0.828
CHTOP	ENSAPLP00000029486	ENSAPLP00000009643	ENSAPLP00000029486	Chromatin target of PRMT1.	Uncharacterized protein.	0.663
CHTOP	POLDIP3	ENSAPLP00000009643	ENSAPLP00000004745	Chromatin target of PRMT1.	DNA polymerase delta interacting protein 3.	0.773
CHTOP	THOC1	ENSAPLP00000009643	ENSAPLP00000027764	Chromatin target of PRMT1.	THO complex 1.	0.836
CHTOP	THOC2	ENSAPLP00000009643	ENSAPLP00000018283	Chromatin target of PRMT1.	THO complex 2.	0.824
CHTOP	THOC3	ENSAPLP00000009643	ENSAPLP00000031684	Chromatin target of PRMT1.	THO complex 3.	0.751
CHTOP	THOC5	ENSAPLP00000009643	ENSAPLP00000026952	Chromatin target of PRMT1.	Uncharacterized protein.	0.775
CHTOP	THOC7	ENSAPLP00000009643	ENSAPLP00000002801	Chromatin target of PRMT1.	THO complex 7.	0.806
CHTOP	ZC3H13	ENSAPLP00000009643	ENSAPLP00000030123	Chromatin target of PRMT1.	Zinc finger CCCH-type containing 13.	0.576
ENSAPLP00000020998	ENSAPLP00000029053	ENSAPLP00000020998	ENSAPLP00000029053	NTF2 domain-containing protein.	RRM domain-containing protein.	0.993
ENSAPLP00000020998	ENSAPLP00000029486	ENSAPLP00000020998	ENSAPLP00000029486	NTF2 domain-containing protein.	Uncharacterized protein.	0.788
ENSAPLP00000020998	POLDIP3	ENSAPLP00000020998	ENSAPLP00000004745	NTF2 domain-containing protein.	DNA polymerase delta interacting protein 3.	0.946
ENSAPLP00000020998	THOC1	ENSAPLP00000020998	ENSAPLP00000027764	NTF2 domain-containing protein.	THO complex 1.	0.786
ENSAPLP00000020998	THOC2	ENSAPLP00000020998	ENSAPLP00000018283	NTF2 domain-containing protein.	THO complex 2.	0.772
ENSAPLP00000020998	THOC3	ENSAPLP00000020998	ENSAPLP00000031684	NTF2 domain-containing protein.	THO complex 3.	0.690
ENSAPLP00000020998	THOC5	ENSAPLP00000020998	ENSAPLP00000026952	NTF2 domain-containing protein.	Uncharacterized protein.	0.788
ENSAPLP00000020998	THOC7	ENSAPLP00000020998	ENSAPLP00000002801	NTF2 domain-containing protein.	THO complex 7.	0.843
ENSAPLP00000020998	ZC3H13	ENSAPLP00000020998	ENSAPLP00000030123	NTF2 domain-containing protein.	Zinc finger CCCH-type containing 13.	0.678
ENSAPLP00000029053	CHTOP	ENSAPLP00000029053	ENSAPLP00000009643	RRM domain-containing protein.	Chromatin target of PRMT1.	0.828
ENSAPLP00000029053	ENSAPLP00000020998	ENSAPLP00000029053	ENSAPLP00000020998	RRM domain-containing protein.	NTF2 domain-containing protein.	0.993

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.863

expected number of edges:

12

PPI enrichment p-value:

0.000464

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033108

Mitochondrial respiratory chain complex assembly

7 of 47

1.95

3.64

2.62e-09

GO:0033617

Mitochondrial cytochrome c oxidase assembly

5 of 29

2.01

2.69

2.00e-06

GO:0007005

Mitochondrion organization

9 of 274

1.29

1.84

5.45e-08

GO:0065003

Protein-containing complex assembly

8 of 488

0.99

0.95

0.00011

GO:0016043

Cellular component organization

10 of 1889

0.5

0.35

0.0153

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005507

Copper ion binding

4 of 22

2.04

1.91

0.00015

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

9 of 69

1.89

4.65

1.55e-13

GO:0005740

Mitochondrial envelope

10 of 466

1.11

1.46

1.23e-08

GO:0005743

Mitochondrial inner membrane

5 of 269

1.05

0.78

0.0042

GO:0031966

Mitochondrial membrane

6 of 422

0.93

0.72

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33498264

(2021) Regulation of COX Assembly and Function by Twin CX9C Proteins-Implications for Human Disease.

6 of 16

2.35

3.81

2.66e-08

PMID:18761382

(2009) Redox regulation of protein folding in the mitochondrial intermembrane space.

6 of 34

2.02

2.89

6.77e-07

PMID:28886682

(2017) Copper Acquisition and Utilization in Fungi.

6 of 36

2.0

2.86

6.77e-07

PMID:34557489

(2021) Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.

6 of 47

1.88

2.56

2.01e-06

PMID:29495437

(2018) The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants.

5 of 25

2.08

2.44

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2974

Respiratory chain complex IV assembly, and Heme a metabolic process

9 of 18

2.48

8.1

5.75e-18

CL:2995

Mixed, incl. CHCH domain, and Cytochrome c oxidase biogenesis protein Cmc1 like

4 of 6

2.6

3.49

2.57e-07

CL:2977

Copper chaperone activity, and Cytochrome oxidase c subunit VIb

3 of 5

2.56

2.32

4.72e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 59

1.91

4.21

1.45e-11

GOCC:1902695

Metallochaperone complex

3 of 4

2.65

2.52

2.12e-05

GOCC:0005740

Mitochondrial envelope

9 of 368

1.17

1.52

1.20e-07

GOCC:0005739

Mitochondrion

10 of 851

0.85

0.87

2.70e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

8 of 97

1.69

3.31

1.73e-10

KW-0186

Copper

4 of 27

1.95

2.29

1.50e-05

KW-0496

Mitochondrion

10 of 807

0.87

0.91

1.36e-06

KW-0999

Mitochondrion inner membrane

4 of 213

1.05

0.6

0.0273

KW-0143

Chaperone

3 of 105

1.23

0.6

0.0448

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08583

Cytochrome c oxidase biogenesis protein Cmc1 like

2 of 2

2.78

1.06

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013892

Cytochrome c oxidase biogenesis protein Cmc1-like

2 of 2

2.78

0.78

0.0390

IPR009069

Cysteine alpha-hairpin motif superfamily

2 of 3

2.6

0.78

0.0390

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