ENSAPLP00000028079 protein (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSAPLP00000028079

Uncharacterized protein. (581 aa)

Predicted Functional Partners:

LTB4R

0.681

USP7

0.637

U3J297_ANAPP

0.594

LNX1

0.550

TRIM33

0.521

U3IER8_ANAPP

0.493

TSSK3

0.481

VPS35

0.480

NSMCE1

0.479

ENSAPLP00000026678

0.455

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000026678	ENSAPLP00000028079	ENSAPLP00000026678	ENSAPLP00000028079	Uncharacterized protein.	Uncharacterized protein.	0.455
ENSAPLP00000026678	LTB4R	ENSAPLP00000026678	ENSAPLP00000022770	Uncharacterized protein.	Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family.	0.611
ENSAPLP00000026678	U3IER8_ANAPP	ENSAPLP00000026678	ENSAPLP00000005740	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.620
ENSAPLP00000026678	U3J297_ANAPP	ENSAPLP00000026678	ENSAPLP00000013624	Uncharacterized protein.	C-type lectin domain-containing protein.	0.617
ENSAPLP00000028079	ENSAPLP00000026678	ENSAPLP00000028079	ENSAPLP00000026678	Uncharacterized protein.	Uncharacterized protein.	0.455
ENSAPLP00000028079	LNX1	ENSAPLP00000028079	ENSAPLP00000002890	Uncharacterized protein.	Ligand of numb-protein X 1.	0.550
ENSAPLP00000028079	LTB4R	ENSAPLP00000028079	ENSAPLP00000022770	Uncharacterized protein.	Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family.	0.681
ENSAPLP00000028079	NSMCE1	ENSAPLP00000028079	ENSAPLP00000014974	Uncharacterized protein.	NSE1 homolog, SMC5-SMC6 complex component.	0.479
ENSAPLP00000028079	TRIM33	ENSAPLP00000028079	ENSAPLP00000010241	Uncharacterized protein.	Tripartite motif containing 33.	0.521
ENSAPLP00000028079	TSSK3	ENSAPLP00000028079	ENSAPLP00000012029	Uncharacterized protein.	Testis specific serine kinase 3.	0.481
ENSAPLP00000028079	U3IER8_ANAPP	ENSAPLP00000028079	ENSAPLP00000005740	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.493
ENSAPLP00000028079	U3J297_ANAPP	ENSAPLP00000028079	ENSAPLP00000013624	Uncharacterized protein.	C-type lectin domain-containing protein.	0.594
ENSAPLP00000028079	USP7	ENSAPLP00000028079	ENSAPLP00000021382	Uncharacterized protein.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.637
ENSAPLP00000028079	VPS35	ENSAPLP00000028079	ENSAPLP00000021755	Uncharacterized protein.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.480
LNX1	ENSAPLP00000028079	ENSAPLP00000002890	ENSAPLP00000028079	Ligand of numb-protein X 1.	Uncharacterized protein.	0.550
LTB4R	ENSAPLP00000026678	ENSAPLP00000022770	ENSAPLP00000026678	Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.611
LTB4R	ENSAPLP00000028079	ENSAPLP00000022770	ENSAPLP00000028079	Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.681
LTB4R	U3IER8_ANAPP	ENSAPLP00000022770	ENSAPLP00000005740	Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.617
LTB4R	U3J297_ANAPP	ENSAPLP00000022770	ENSAPLP00000013624	Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family.	C-type lectin domain-containing protein.	0.555
NSMCE1	ENSAPLP00000028079	ENSAPLP00000014974	ENSAPLP00000028079	NSE1 homolog, SMC5-SMC6 complex component.	Uncharacterized protein.	0.479

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.802

expected number of edges:

11

PPI enrichment p-value:

2.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045638

Negative regulation of myeloid cell differentiation

4 of 65

2.05

1.87

0.00019

GO:0045637

Regulation of myeloid cell differentiation

5 of 151

1.78

1.81

0.00012

GO:0045596

Negative regulation of cell differentiation

6 of 451

1.39

0.00019

GO:0007389

Pattern specification process

5 of 328

1.45

1.36

0.00039

GO:0009880

Embryonic pattern specification

3 of 55

2.0

1.34

0.0025

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

9 of 969

1.23

1.66

1.06e-07

GO:0003700

DNA-binding transcription factor activity

10 of 1187

1.19

1.64

1.60e-08

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

5 of 326

1.45

1.52

0.00010

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

9 of 1118

1.17

1.51

1.51e-07

GO:0003677

DNA binding

10 of 2214

0.92

1.0

6.34e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22829811

(2012) Epigenetic alterations in bladder cancer and their potential clinical implications.

4 of 17

2.64

2.58

1.63e-05

PMID:22495965

(2012) A novel 13 base pair insertion in the sonic hedgehog ZRS limb enhancer (ZRSLMBR1) causes preaxial polydactyly with triphalangeal thumb.

3 of 9

2.79

1.71

0.00076

PMID:26572684

(2015) Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRLMpJ mouse.

3 of 11

2.7

1.68

0.00084

PMID:36418415

(2022) The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.

3 of 13

2.63

1.64

0.00097

PMID:28874668

(2017) Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation.

3 of 19

2.46

1.45

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26589

Embryonic skeletal system morphogenesis, and N-terminal of Homeobox Meis and PKNOX1

6 of 25

2.64

5.58

1.61e-11

CL:26624

Mixed, incl. Protein of unknown function (DUF3528), and N-terminal of Homeobox Meis and PKNOX1

4 of 5

3.17

4.61

3.85e-09

CL:26433

Homeobox, and Neuron fate commitment

7 of 125

2.01

4.2

1.26e-10

CL:32174

Mixed, incl. Adiponectin binding, and G2 nidogen domain and fibulin

2 of 7

2.72

1.24

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa05202

Transcriptional misregulation in cancer

4 of 141

1.72

1.63

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 3900

0.63

0.4

0.0259

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0371

Homeobox

7 of 203

1.8

3.38

1.55e-09

KW-0238

DNA-binding

8 of 642

1.36

2.01

3.42e-08

KW-0539

Nucleus

8 of 1146

1.11

1.29

2.14e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16493

N-terminal of Homeobox Meis and PKNOX1

2 of 5

2.87

1.04

0.0130

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00389

Homeodomain

7 of 208

1.79

3.25

3.60e-09

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About