SOST protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

SOST

Sclerostin. (328 aa)

Predicted Functional Partners:

LRP6

0.999

LRP5

0.989

VRK3

0.816

DKK1

0.776

TNFSF11

0.748

PHEX

0.748

PTH

0.742

U3I5F9_ANAPP

0.612

TNFRSF11B

0.611

DKK2

0.610

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DKK1	DKK2	ENSAPLP00000021199	ENSAPLP00000005731	Dickkopf WNT signaling pathway inhibitor 1.	Dickkopf_N domain-containing protein.	0.611
DKK1	LRP5	ENSAPLP00000021199	ENSAPLP00000007976	Dickkopf WNT signaling pathway inhibitor 1.	Uncharacterized protein.	0.892
DKK1	LRP6	ENSAPLP00000021199	ENSAPLP00000012018	Dickkopf WNT signaling pathway inhibitor 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.997
DKK1	SOST	ENSAPLP00000021199	ENSAPLP00000028420	Dickkopf WNT signaling pathway inhibitor 1.	Sclerostin.	0.776
DKK1	TNFSF11	ENSAPLP00000021199	ENSAPLP00000004967	Dickkopf WNT signaling pathway inhibitor 1.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.494
DKK2	DKK1	ENSAPLP00000005731	ENSAPLP00000021199	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 1.	0.611
DKK2	LRP5	ENSAPLP00000005731	ENSAPLP00000007976	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.982
DKK2	LRP6	ENSAPLP00000005731	ENSAPLP00000012018	Dickkopf_N domain-containing protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.990
DKK2	SOST	ENSAPLP00000005731	ENSAPLP00000028420	Dickkopf_N domain-containing protein.	Sclerostin.	0.610
LRP5	DKK1	ENSAPLP00000007976	ENSAPLP00000021199	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1.	0.892
LRP5	DKK2	ENSAPLP00000007976	ENSAPLP00000005731	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.982
LRP5	LRP6	ENSAPLP00000007976	ENSAPLP00000012018	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.978
LRP5	PTH	ENSAPLP00000007976	ENSAPLP00000004644	Uncharacterized protein.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.461
LRP5	SOST	ENSAPLP00000007976	ENSAPLP00000028420	Uncharacterized protein.	Sclerostin.	0.989
LRP6	DKK1	ENSAPLP00000012018	ENSAPLP00000021199	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf WNT signaling pathway inhibitor 1.	0.997
LRP6	DKK2	ENSAPLP00000012018	ENSAPLP00000005731	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.990
LRP6	LRP5	ENSAPLP00000012018	ENSAPLP00000007976	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.978
LRP6	SOST	ENSAPLP00000012018	ENSAPLP00000028420	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Sclerostin.	0.999
PHEX	PTH	ENSAPLP00000012390	ENSAPLP00000004644	Phosphate regulating endopeptidase homolog X-linked.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.595
PHEX	SOST	ENSAPLP00000012390	ENSAPLP00000028420	Phosphate regulating endopeptidase homolog X-linked.	Sclerostin.	0.748