ENSAPLP00000028671 protein (Anas platyrhynchos)

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSAPLP00000028671

Uncharacterized protein. (354 aa)

Predicted Functional Partners:

KDSR

0.933

DEGS2

0.926

DEGS1

0.926

SPHK1

0.922

U3I4F0_ANAPP

0.920

CERK

0.919

ACER1

0.919

ACER2

0.919

SGPP2

0.916

PLPP2

0.912

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACER1	ACER2	ENSAPLP00000003332	ENSAPLP00000022666	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.905
ACER1	CERK	ENSAPLP00000003332	ENSAPLP00000003206	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Ceramide kinase.	0.954
ACER1	DEGS1	ENSAPLP00000003332	ENSAPLP00000012405	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Delta 4-desaturase, sphingolipid 1.	0.926
ACER1	DEGS2	ENSAPLP00000003332	ENSAPLP00000003095	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Delta 4-desaturase, sphingolipid 2.	0.927
ACER1	ENSAPLP00000028671	ENSAPLP00000003332	ENSAPLP00000028671	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Uncharacterized protein.	0.919
ACER1	PLPP2	ENSAPLP00000003332	ENSAPLP00000001855	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Phospholipid phosphatase 2.	0.914
ACER1	SGPP2	ENSAPLP00000003332	ENSAPLP00000010640	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingosine-1-phosphate phosphatase 2.	0.915
ACER1	SPHK1	ENSAPLP00000003332	ENSAPLP00000019504	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingosine kinase 1.	0.945
ACER1	U3I4F0_ANAPP	ENSAPLP00000003332	ENSAPLP00000002121	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Neutral ceramidase.	0.962
ACER2	ACER1	ENSAPLP00000022666	ENSAPLP00000003332	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.905
ACER2	CERK	ENSAPLP00000022666	ENSAPLP00000003206	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Ceramide kinase.	0.954
ACER2	DEGS1	ENSAPLP00000022666	ENSAPLP00000012405	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Delta 4-desaturase, sphingolipid 1.	0.918
ACER2	DEGS2	ENSAPLP00000022666	ENSAPLP00000003095	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Delta 4-desaturase, sphingolipid 2.	0.924
ACER2	ENSAPLP00000028671	ENSAPLP00000022666	ENSAPLP00000028671	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Uncharacterized protein.	0.919
ACER2	PLPP2	ENSAPLP00000022666	ENSAPLP00000001855	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Phospholipid phosphatase 2.	0.914
ACER2	SGPP2	ENSAPLP00000022666	ENSAPLP00000010640	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingosine-1-phosphate phosphatase 2.	0.922
ACER2	SPHK1	ENSAPLP00000022666	ENSAPLP00000019504	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingosine kinase 1.	0.948
ACER2	U3I4F0_ANAPP	ENSAPLP00000022666	ENSAPLP00000002121	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Neutral ceramidase.	0.960
CERK	ACER1	ENSAPLP00000003206	ENSAPLP00000003332	Ceramide kinase.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.954
CERK	ACER2	ENSAPLP00000003206	ENSAPLP00000022666	Ceramide kinase.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.954

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.958

expected number of edges:

10

PPI enrichment p-value:

3.14e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001941

Postsynaptic membrane organization

4 of 20

2.56

2.96

2.74e-06

GO:0099173

Postsynapse organization

5 of 59

2.19

2.92

1.35e-06

GO:0097104

Postsynaptic membrane assembly

3 of 5

3.04

2.72

1.12e-05

GO:0097105

Presynaptic membrane assembly

3 of 7

2.9

2.6

1.74e-05

GO:0007158

Neuron cell-cell adhesion

3 of 8

2.84

2.57

1.96e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042043

Neurexin family protein binding

3 of 11

2.7

2.12

0.00013

GO:0035255

Ionotropic glutamate receptor binding

2 of 12

2.49

0.79

0.0367

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099572

Postsynaptic specialization

6 of 194

1.75

2.56

5.96e-07

GO:0099634

Postsynaptic specialization membrane

4 of 79

1.97

2.11

4.39e-05

GO:0099060

Integral component of postsynaptic specialization membrane

3 of 45

2.09

1.74

0.00039

GO:0045202

Synapse

7 of 932

1.14

1.19

4.39e-05

GO:0032281

AMPA glutamate receptor complex

2 of 22

2.22

1.16

0.0067

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26747202

(2016) Whole-Genome Sequencing of a Canine Family Trio Reveals a FAM83G Variant Associated with Hereditary Footpad Hyperkeratosis.

4 of 10

2.87

3.03

2.73e-06

PMID:35012288

(2021) Genetic analysis of the postsynaptic transmembrane X-linked neuroligin 3 gene in autism.

3 of 7

2.9

1.86

0.00041

PMID:31371581

(2019) Somatic evolution and global expansion of an ancient transmissible cancer lineage.

3 of 8

2.84

1.86

0.00041

PMID:28713278

(2017) The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins.

3 of 9

2.79

1.86

0.00041

PMID:34755500

(2021) Understanding autism spectrum disorders with animal models: applications, insights, and perspectives.

3 of 33

2.22

1.08

0.0098

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20133

Neurexins and neuroligins, and NMDA glutamate receptor activity

8 of 27

2.74

8.42

2.53e-17

CL:20136

Postsynaptic membrane assembly, and Neurexins and neuroligins

4 of 10

2.87

4.02

3.56e-08

CL:20161

NMDA glutamate receptor activity, and Polyubiquitination (PEST) N-terminal domain of MAGUK

3 of 13

2.63

2.36

4.31e-05

CL:20138

Postsynaptic membrane assembly, and Putative band 4.1 homologues binding motif

2 of 5

2.87

1.38

0.0032

CL:22783

Mixed, incl. PLD-like domain, and DMAP1-binding Domain

2 of 7

2.72

1.28

0.0048

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04514

Cell adhesion molecules

3 of 113

1.69

0.99

0.0098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-6794361

Neurexins and neuroligins

8 of 28

2.72

8.55

1.16e-17

CFA-438066

Unblocking of NMDA receptors, glutamate binding and activation

3 of 16

2.54

2.32

4.63e-05

CFA-451308

Activation of Ca-permeable Kainate Receptor

2 of 10

2.56

1.27

0.0047

CFA-8849932

Synaptic adhesion-like molecules

2 of 15

2.39

1.16

0.0073

CFA-5673001

RAF/MAP kinase cascade

3 of 240

1.36

0.67

0.0352

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000142

Brain

9 of 2572

0.81

0.67

0.00079

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0099572

Postsynaptic specialization

4 of 97

1.88

1.68

0.00035

GOCC:0045202

Synapse

5 of 419

1.34

1.11

0.0015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0728

SH3 domain

4 of 204

1.56

1.26

0.0014

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07859

Alpha/beta hydrolase fold

3 of 13

2.63

2.07

0.00015

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00072

Guanylate kinase homologues.

3 of 25

2.34

1.85

0.00032

SM01277

Polyubiquitination (PEST) N-terminal domain of MAGUK

2 of 3

3.09

1.74

0.00072

SM00228

Domain present in PSD-95, Dlg, and ZO-1/2.

4 of 148

1.7

1.55

0.00039

SM00326

Src homology 3 domains

4 of 200

1.56

1.37

0.00072

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