BTBD11 protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

BTBD11

BTB domain containing 11. (1086 aa)

Predicted Functional Partners:

RIC8B

0.636

NRAP

0.606

NUAK1

0.602

PPFIBP1

0.592

ENSAPLP00000025176

0.592

MIB2

0.443

UBXN7

0.443

BBS7

0.431

PLS3

0.431

ZFHX4

0.412

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS7	BTBD11	ENSAPLP00000004851	ENSAPLP00000028863	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	BTB domain containing 11.	0.431
BTBD11	BBS7	ENSAPLP00000028863	ENSAPLP00000004851	BTB domain containing 11.	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	0.431
BTBD11	ENSAPLP00000025176	ENSAPLP00000028863	ENSAPLP00000025176	BTB domain containing 11.	Uncharacterized protein.	0.592
BTBD11	MIB2	ENSAPLP00000028863	ENSAPLP00000010472	BTB domain containing 11.	Mindbomb E3 ubiquitin protein ligase 2.	0.443
BTBD11	NRAP	ENSAPLP00000028863	ENSAPLP00000025922	BTB domain containing 11.	Nebulin related anchoring protein.	0.606
BTBD11	NUAK1	ENSAPLP00000028863	ENSAPLP00000031494	BTB domain containing 11.	NUAK family kinase 1.	0.602
BTBD11	PLS3	ENSAPLP00000028863	ENSAPLP00000010885	BTB domain containing 11.	Plastin 3.	0.431
BTBD11	PPFIBP1	ENSAPLP00000028863	ENSAPLP00000009059	BTB domain containing 11.	Uncharacterized protein.	0.592
BTBD11	RIC8B	ENSAPLP00000028863	ENSAPLP00000007748	BTB domain containing 11.	RIC8 guanine nucleotide exchange factor B.	0.636
BTBD11	UBXN7	ENSAPLP00000028863	ENSAPLP00000024434	BTB domain containing 11.	UBX domain-containing protein 7.	0.443
BTBD11	ZFHX4	ENSAPLP00000028863	ENSAPLP00000012696	BTB domain containing 11.	Zinc finger homeobox 4.	0.412
ENSAPLP00000025176	BTBD11	ENSAPLP00000025176	ENSAPLP00000028863	Uncharacterized protein.	BTB domain containing 11.	0.592
ENSAPLP00000025176	PPFIBP1	ENSAPLP00000025176	ENSAPLP00000009059	Uncharacterized protein.	Uncharacterized protein.	0.925
ENSAPLP00000025176	RIC8B	ENSAPLP00000025176	ENSAPLP00000007748	Uncharacterized protein.	RIC8 guanine nucleotide exchange factor B.	0.459
MIB2	BTBD11	ENSAPLP00000010472	ENSAPLP00000028863	Mindbomb E3 ubiquitin protein ligase 2.	BTB domain containing 11.	0.443
MIB2	UBXN7	ENSAPLP00000010472	ENSAPLP00000024434	Mindbomb E3 ubiquitin protein ligase 2.	UBX domain-containing protein 7.	0.407
NRAP	BTBD11	ENSAPLP00000025922	ENSAPLP00000028863	Nebulin related anchoring protein.	BTB domain containing 11.	0.606
NUAK1	BTBD11	ENSAPLP00000031494	ENSAPLP00000028863	NUAK family kinase 1.	BTB domain containing 11.	0.602
NUAK1	RIC8B	ENSAPLP00000031494	ENSAPLP00000007748	NUAK family kinase 1.	RIC8 guanine nucleotide exchange factor B.	0.586
PLS3	BTBD11	ENSAPLP00000010885	ENSAPLP00000028863	Plastin 3.	BTB domain containing 11.	0.431

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

0.232

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

9 of 175

2.03

5.27

5.11e-14

GO:0046486

Glycerolipid metabolic process

10 of 342

1.78

4.32

5.11e-14

GO:0006629

Lipid metabolic process

11 of 1175

1.29

2.15

1.13e-11

GO:0045017

Glycerolipid biosynthetic process

5 of 205

1.7

2.0

2.23e-05

GO:0043647

Inositol phosphate metabolic process

3 of 34

2.26

1.8

0.00037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004435

Phosphatidylinositol phospholipase C activity

4 of 24

2.54

3.22

7.90e-07

GO:0042578

Phosphoric ester hydrolase activity

8 of 473

1.55

2.52

1.51e-08

GO:0046030

Inositol trisphosphate phosphatase activity

2 of 17

2.39

1.12

0.0087

GO:0016791

Phosphatase activity

4 of 351

1.37

0.99

0.0046

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

2 of 45

1.97

0.71

0.0463

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27029

Inositol phosphate metabolism, and Inositol hexakisphosphate 5-kinase activity

9 of 84

2.35

7.32

5.58e-17

CL:27030

Inositol phosphate metabolism

8 of 67

2.39

6.88

1.86e-15

CL:27032

Inositol phosphate metabolism

7 of 45

2.51

6.48

6.76e-14

CL:27033

Inositol phosphate metabolism

6 of 39

2.5

5.46

1.34e-11

CL:27060

Mixed, incl. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain, and 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain

4 of 10

2.92

4.19

1.81e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret00562

Inositol phosphate metabolism

11 of 82

2.45

10.56

4.53e-25

pret04070

Phosphatidylinositol signaling system

11 of 88

2.41

10.39

4.68e-25

pret01100

Metabolic pathways

11 of 1488

1.19

1.85

5.14e-12

pret04020

Calcium signaling pathway

4 of 250

1.52

0.00019

pret04370

VEGF signaling pathway

2 of 64

1.81

0.94

0.0147

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

8 of 73

2.36

6.63

4.73e-15

MAP-1855204

Synthesis of IP3 and IP4 in the cytosol

5 of 45

2.36

3.92

1.55e-08

MAP-1660517

Synthesis of PIPs at the late endosome membrane

2 of 7

2.77

1.38

0.0031

MAP-202403

TCR signaling

3 of 80

1.89

1.27

0.0031

MAP-1660516

Synthesis of PIPs at the early endosome membrane

2 of 15

2.44

1.18

0.0068

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0443

Lipid metabolism

5 of 102

2.01

3.0

3.08e-07

KW-0442

Lipid degradation

3 of 45

2.14

1.86

0.00024

KW-0378

Hydrolase

5 of 768

1.13

0.92

0.0019

KW-0807

Transducer

4 of 562

1.17

0.79

0.0089

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001711

Phospholipase C, phosphatidylinositol-specific, Y domain

4 of 23

2.56

2.9

3.59e-06

IPR001192

Phosphoinositide phospholipase C family

4 of 23

2.56

2.9

3.59e-06

IPR000909

Phosphatidylinositol-specific phospholipase C, X domain

4 of 29

2.46

2.86

3.59e-06

IPR017946

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

4 of 40

2.32

2.66

6.91e-06

IPR035892

C2 domain superfamily

5 of 228

1.66

1.79

6.56e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00149

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00148

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 185

1.65

1.53

0.00037

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