SLC1A6 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

SLC1A6

Amino acid transporter. (572 aa)

Predicted Functional Partners:

SLC7A1

0.758

SLC15A1

0.756

SLC38A2

0.750

SLC7A5

0.673

SLC7A9

0.666

SLC2A2

0.644

SLC6A19

0.617

SLC7A2

0.611

SLC6A15

0.589

SLC38A1

0.554

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SLC15A1	SLC1A6	ENSAPLP00000003040	ENSAPLP00000028952	Solute carrier family 15 member 1.	Amino acid transporter.	0.756
SLC15A1	SLC2A2	ENSAPLP00000003040	ENSAPLP00000009920	Solute carrier family 15 member 1.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.762
SLC15A1	SLC38A2	ENSAPLP00000003040	ENSAPLP00000027226	Solute carrier family 15 member 1.	Solute carrier family 38 member 2.	0.479
SLC15A1	SLC6A19	ENSAPLP00000003040	ENSAPLP00000005578	Solute carrier family 15 member 1.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.612
SLC15A1	SLC7A1	ENSAPLP00000003040	ENSAPLP00000032403	Solute carrier family 15 member 1.	Solute carrier family 7 member 1.	0.652
SLC15A1	SLC7A2	ENSAPLP00000003040	ENSAPLP00000030609	Solute carrier family 15 member 1.	Solute carrier family 7 member 2.	0.618
SLC15A1	SLC7A9	ENSAPLP00000003040	ENSAPLP00000005980	Solute carrier family 15 member 1.	Solute carrier family 7 member 9.	0.772
SLC1A6	SLC15A1	ENSAPLP00000028952	ENSAPLP00000003040	Amino acid transporter.	Solute carrier family 15 member 1.	0.756
SLC1A6	SLC2A2	ENSAPLP00000028952	ENSAPLP00000009920	Amino acid transporter.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.644
SLC1A6	SLC38A1	ENSAPLP00000028952	ENSAPLP00000009800	Amino acid transporter.	Solute carrier family 38 member 1.	0.554
SLC1A6	SLC38A2	ENSAPLP00000028952	ENSAPLP00000027226	Amino acid transporter.	Solute carrier family 38 member 2.	0.750
SLC1A6	SLC6A15	ENSAPLP00000028952	ENSAPLP00000015109	Amino acid transporter.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.589
SLC1A6	SLC6A19	ENSAPLP00000028952	ENSAPLP00000005578	Amino acid transporter.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.617
SLC1A6	SLC7A1	ENSAPLP00000028952	ENSAPLP00000032403	Amino acid transporter.	Solute carrier family 7 member 1.	0.758
SLC1A6	SLC7A2	ENSAPLP00000028952	ENSAPLP00000030609	Amino acid transporter.	Solute carrier family 7 member 2.	0.611
SLC1A6	SLC7A5	ENSAPLP00000028952	ENSAPLP00000024256	Amino acid transporter.	Solute carrier family 7 member 5.	0.673
SLC1A6	SLC7A9	ENSAPLP00000028952	ENSAPLP00000005980	Amino acid transporter.	Solute carrier family 7 member 9.	0.666
SLC2A2	SLC15A1	ENSAPLP00000009920	ENSAPLP00000003040	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Solute carrier family 15 member 1.	0.762
SLC2A2	SLC1A6	ENSAPLP00000009920	ENSAPLP00000028952	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Amino acid transporter.	0.644
SLC2A2	SLC6A19	ENSAPLP00000009920	ENSAPLP00000005578	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.405

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Network Stats

number of nodes:

11

number of edges:

14

average node degree:

2.55

avg. local clustering coefficient:

0.887

expected number of edges:

10

PPI enrichment p-value:

0.144

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044772

Mitotic cell cycle phase transition

6 of 120

1.96

3.11

1.08e-07

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

3 of 3

3.26

3.06

2.90e-06

GO:0031145

Anaphase-promoting complex-dependent catabolic process

3 of 19

2.46

2.18

8.35e-05

GO:0000079

Regulation of cyclin-dependent protein serine/threonine kinase activity

4 of 73

2.0

2.16

3.82e-05

GO:0031396

Regulation of protein ubiquitination

5 of 171

1.73

2.06

1.76e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

3 of 4

3.14

2.7

1.26e-05

GO:0010997

Anaphase-promoting complex binding

3 of 9

2.79

2.56

1.98e-05

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

4 of 51

2.16

2.4

1.70e-05

GO:0043125

ErbB-3 class receptor binding

2 of 4

2.96

1.63

0.0011

GO:0030549

Acetylcholine receptor activator activity

2 of 4

2.96

1.63

0.0011

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

6 of 51

2.33

4.66

2.70e-10

GO:0005680

Anaphase-promoting complex

3 of 21

2.42

2.26

5.31e-05

GO:1990234

Transferase complex

9 of 815

1.31

1.96

7.84e-09

GO:0016533

Protein kinase 5 complex

2 of 4

2.96

1.77

0.00062

GO:0031461

cullin-RING ubiquitin ligase complex

4 of 177

1.62

1.51

0.00037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8864

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

4 of 77

1.98

1.72

0.00035

CL:8865

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

3 of 69

1.9

0.94

0.0158

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-176417

Phosphorylation of Emi1

2 of 7

2.72

1.12

0.0094

CFA-174113

SCF-beta-TrCP mediated degradation of Emi1

2 of 8

2.66

1.12

0.0094

CFA-69656

Cyclin A:Cdk2-associated events at S phase entry

3 of 65

1.93

1.05

0.0094

CFA-176407

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

2 of 20

2.26

0.9

0.0220

CFA-69231

Cyclin D associated events in G1

2 of 38

1.99

0.76

0.0370

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

3 of 34

2.21

1.79

0.00038

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

3 of 42

2.12

1.49

0.0014

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