PPIL1 protein (Anas platyrhynchos) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

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PPIL1

Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)

Predicted Functional Partners:

CDC40

0.992

SNW1

0.989

SYF2

0.987

CDC5L

0.974

EFTUD2

0.969

PRPF8

0.965

AQR

0.955

PRPF19

0.949

BUD31

0.941

SNRPG

0.934

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQR	BUD31	ENSAPLP00000007867	ENSAPLP00000006361	Aquarius intron-binding spliceosomal factor.	BUD31 homolog.	0.990
AQR	CDC40	ENSAPLP00000007867	ENSAPLP00000013844	Aquarius intron-binding spliceosomal factor.	Cell division cycle 40.	0.970
AQR	CDC5L	ENSAPLP00000007867	ENSAPLP00000028202	Aquarius intron-binding spliceosomal factor.	Cell division cycle 5 like.	0.981
AQR	EFTUD2	ENSAPLP00000007867	ENSAPLP00000024550	Aquarius intron-binding spliceosomal factor.	Elongation factor Tu GTP binding domain containing 2.	0.983
AQR	PPIL1	ENSAPLP00000007867	ENSAPLP00000029001	Aquarius intron-binding spliceosomal factor.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.955
AQR	PRPF19	ENSAPLP00000007867	ENSAPLP00000020287	Aquarius intron-binding spliceosomal factor.	Pre-mRNA processing factor 19.	0.997
AQR	PRPF8	ENSAPLP00000007867	ENSAPLP00000010131	Aquarius intron-binding spliceosomal factor.	Pre-mRNA processing factor 8.	0.975
AQR	SNRPG	ENSAPLP00000007867	ENSAPLP00000003436	Aquarius intron-binding spliceosomal factor.	Small nuclear ribonucleoprotein polypeptide G.	0.911
AQR	SNW1	ENSAPLP00000007867	ENSAPLP00000015649	Aquarius intron-binding spliceosomal factor.	SNW domain containing 1.	0.984
AQR	SYF2	ENSAPLP00000007867	ENSAPLP00000026635	Aquarius intron-binding spliceosomal factor.	SYF2 pre-mRNA splicing factor.	0.881
BUD31	AQR	ENSAPLP00000006361	ENSAPLP00000007867	BUD31 homolog.	Aquarius intron-binding spliceosomal factor.	0.990
BUD31	CDC40	ENSAPLP00000006361	ENSAPLP00000013844	BUD31 homolog.	Cell division cycle 40.	0.981
BUD31	CDC5L	ENSAPLP00000006361	ENSAPLP00000028202	BUD31 homolog.	Cell division cycle 5 like.	0.982
BUD31	EFTUD2	ENSAPLP00000006361	ENSAPLP00000024550	BUD31 homolog.	Elongation factor Tu GTP binding domain containing 2.	0.985
BUD31	PPIL1	ENSAPLP00000006361	ENSAPLP00000029001	BUD31 homolog.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.941
BUD31	PRPF19	ENSAPLP00000006361	ENSAPLP00000020287	BUD31 homolog.	Pre-mRNA processing factor 19.	0.976
BUD31	PRPF8	ENSAPLP00000006361	ENSAPLP00000010131	BUD31 homolog.	Pre-mRNA processing factor 8.	0.981
BUD31	SNRPG	ENSAPLP00000006361	ENSAPLP00000003436	BUD31 homolog.	Small nuclear ribonucleoprotein polypeptide G.	0.974
BUD31	SNW1	ENSAPLP00000006361	ENSAPLP00000015649	BUD31 homolog.	SNW domain containing 1.	0.997
BUD31	SYF2	ENSAPLP00000006361	ENSAPLP00000026635	BUD31 homolog.	SYF2 pre-mRNA splicing factor.	0.982

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006487

Protein N-linked glycosylation

7 of 22

2.28

5.16

1.01e-11

GO:0006486

Protein glycosylation

8 of 63

1.88

4.09

2.05e-11

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

2 of 2

2.78

1.5

0.0019

GO:0031204

Post-translational protein targeting to membrane, translocation

2 of 3

2.6

1.4

0.0027

GO:0018279

Protein N-linked glycosylation via asparagine

2 of 3

2.6

1.4

0.0027

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008250

Oligosaccharyltransferase complex

6 of 6

2.78

6.51

3.46e-13

GO:0140534

Endoplasmic reticulum protein-containing complex

8 of 29

2.22

5.99

2.32e-14

GO:0005789

Endoplasmic reticulum membrane

10 of 132

1.66

3.82

3.09e-14

GO:0005783

Endoplasmic reticulum

11 of 208

1.5

3.16

2.32e-14

GO:0098796

Membrane protein complex

8 of 171

1.45

2.4

2.39e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6398

Oligosaccharyltransferase complex, and Translocon complex

9 of 11

2.69

9.56

4.65e-20

CL:6362

N-Glycan biosynthesis, and Translocon complex

11 of 32

2.31

8.99

2.20e-22

CL:6401

Oligosaccharyltransferase complex

5 of 5

2.78

5.16

1.84e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gsl00510

N-Glycan biosynthesis

8 of 27

2.25

6.32

4.85e-15

gsl04141

Protein processing in endoplasmic reticulum

8 of 68

1.85

4.24

1.91e-12

gsl00513

Various types of N-glycan biosynthesis

5 of 17

2.25

4.04

4.34e-09

gsl03060

Protein export

2 of 25

1.68

0.85

0.0197

gsl04145

Phagosome

2 of 29

1.62

0.82

0.0216

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5663205

Infectious disease

5 of 27

2.05

2.92

6.51e-07

MAP-1643685

Disease

5 of 34

1.95

2.75

9.26e-07

MAP-446203

Asparagine N-linked glycosylation

6 of 120

1.48

1.88

4.55e-06

MAP-597592

Post-translational protein modification

6 of 400

0.95

0.73

0.0034

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

3 of 84

1.33

0.63

0.0421

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008250

Oligosaccharyltransferase complex

6 of 7

2.71

6.15

1.42e-12

GOCC:0005789

Endoplasmic reticulum membrane

9 of 54

2.0

5.33

1.21e-14

GOCC:0005783

Endoplasmic reticulum

8 of 111

1.64

3.11

2.14e-10

GOCC:0098796

Membrane protein complex

8 of 154

1.49

2.53

2.11e-09

GOCC:0005784

Sec61 translocon complex

2 of 2

2.78

1.69

0.00082

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 31

1.89

2.05

4.52e-05

KW-1133

Transmembrane helix

10 of 1231

0.69

0.62

5.14e-05

KW-0808

Transferase

6 of 748

0.68

0.43

0.0257

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