GNAT3 protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

GNAT3

G protein subunit alpha transducin 3. (354 aa)

Predicted Functional Partners:

GNB3

0.855

GNB4

0.847

GNB1

0.843

PDE6G

0.833

GNGT2

0.812

PDE6C

0.803

GNG13

0.802

GNG11

0.795

RHO

0.775

PDE6B

0.756

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAT3	GNB1	ENSAPLP00000029249	ENSAPLP00000010816	G protein subunit alpha transducin 3.	G protein subunit beta 1.	0.843
GNAT3	GNB3	ENSAPLP00000029249	ENSAPLP00000002795	G protein subunit alpha transducin 3.	G protein subunit beta 3.	0.855
GNAT3	GNB4	ENSAPLP00000029249	ENSAPLP00000012022	G protein subunit alpha transducin 3.	G protein subunit beta 4.	0.847
GNAT3	GNG11	ENSAPLP00000029249	ENSAPLP00000022549	G protein subunit alpha transducin 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.795
GNAT3	GNG13	ENSAPLP00000029249	ENSAPLP00000011608	G protein subunit alpha transducin 3.	G protein subunit gamma 13.	0.802
GNAT3	GNGT2	ENSAPLP00000029249	ENSAPLP00000012380	G protein subunit alpha transducin 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.812
GNAT3	PDE6B	ENSAPLP00000029249	ENSAPLP00000010771	G protein subunit alpha transducin 3.	Phosphodiesterase.	0.756
GNAT3	PDE6C	ENSAPLP00000029249	ENSAPLP00000014019	G protein subunit alpha transducin 3.	Phosphodiesterase.	0.803
GNAT3	PDE6G	ENSAPLP00000029249	ENSAPLP00000015232	G protein subunit alpha transducin 3.	Phosphodiesterase 6G.	0.833
GNAT3	RHO	ENSAPLP00000029249	ENSAPLP00000004771	G protein subunit alpha transducin 3.	Rhodopsin.	0.775
GNB1	GNAT3	ENSAPLP00000010816	ENSAPLP00000029249	G protein subunit beta 1.	G protein subunit alpha transducin 3.	0.843
GNB1	GNB3	ENSAPLP00000010816	ENSAPLP00000002795	G protein subunit beta 1.	G protein subunit beta 3.	0.432
GNB1	GNB4	ENSAPLP00000010816	ENSAPLP00000012022	G protein subunit beta 1.	G protein subunit beta 4.	0.432
GNB1	GNG11	ENSAPLP00000010816	ENSAPLP00000022549	G protein subunit beta 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.940
GNB1	GNG13	ENSAPLP00000010816	ENSAPLP00000011608	G protein subunit beta 1.	G protein subunit gamma 13.	0.971
GNB1	GNGT2	ENSAPLP00000010816	ENSAPLP00000012380	G protein subunit beta 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.879
GNB1	PDE6B	ENSAPLP00000010816	ENSAPLP00000010771	G protein subunit beta 1.	Phosphodiesterase.	0.641
GNB1	RHO	ENSAPLP00000010816	ENSAPLP00000004771	G protein subunit beta 1.	Rhodopsin.	0.739
GNB3	GNAT3	ENSAPLP00000002795	ENSAPLP00000029249	G protein subunit beta 3.	G protein subunit alpha transducin 3.	0.855
GNB3	GNB1	ENSAPLP00000002795	ENSAPLP00000010816	G protein subunit beta 3.	G protein subunit beta 1.	0.432

page 1 of 5

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033353

S-adenosylmethionine cycle

3 of 6

3.32

4.18

3.97e-06

GO:0006730

One-carbon metabolic process

3 of 34

2.56

2.9

0.00012

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004013

Adenosylhomocysteinase activity

3 of 3

3.62

5.1

2.79e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30809531

(2019) ITRAQ-Based Quantitative Proteomics Reveals the Proteome Profiles of Primary Duck Embryo Fibroblast Cells Infected with Duck Tembusu Virus.

3 of 15

2.92

3.43

3.13e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7158

Sulfur amino acid biosynthetic process, and Adenosylhomocysteinase-like

3 of 12

3.02

3.86

8.79e-06

CL:7161

Cysteine biosynthetic process, and Adenosylhomocysteinase-like

2 of 5

3.22

2.46

0.00067

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00270

Cysteine and methionine metabolism

3 of 35

2.55

3.73

7.31e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042172

Adenosylhomocysteinase-like superfamily

3 of 3

3.62

4.82

6.35e-07

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

3 of 3

3.62

4.82

6.35e-07

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

4.82

6.35e-07

IPR000043

Adenosylhomocysteinase-like

3 of 3

3.62

4.82

6.35e-07

IPR036291

NAD(P)-binding domain superfamily

3 of 142

1.94

1.7

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00997

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

5.53

7.62e-08

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