BBX protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

BBX

BBX high mobility group box domain containing. (1025 aa)

Predicted Functional Partners:

ATXN1L

0.622

ATXN1

0.622

BRAT1

0.586

BBOX1

0.489

SCUBE3

0.484

BSX

0.480

LAP3

0.453

PCSK9

0.450

IL17RD

0.447

SIN3B

0.447

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN1	ATXN1L	ENSAPLP00000024271	ENSAPLP00000001135	Ataxin 1.	Ataxin 1 like.	0.922
ATXN1	BBX	ENSAPLP00000024271	ENSAPLP00000029376	Ataxin 1.	BBX high mobility group box domain containing.	0.622
ATXN1L	ATXN1	ENSAPLP00000001135	ENSAPLP00000024271	Ataxin 1 like.	Ataxin 1.	0.922
ATXN1L	BBX	ENSAPLP00000001135	ENSAPLP00000029376	Ataxin 1 like.	BBX high mobility group box domain containing.	0.622
BBOX1	BBX	ENSAPLP00000002404	ENSAPLP00000029376	Gamma-butyrobetaine hydroxylase 1.	BBX high mobility group box domain containing.	0.489
BBX	ATXN1	ENSAPLP00000029376	ENSAPLP00000024271	BBX high mobility group box domain containing.	Ataxin 1.	0.622
BBX	ATXN1L	ENSAPLP00000029376	ENSAPLP00000001135	BBX high mobility group box domain containing.	Ataxin 1 like.	0.622
BBX	BBOX1	ENSAPLP00000029376	ENSAPLP00000002404	BBX high mobility group box domain containing.	Gamma-butyrobetaine hydroxylase 1.	0.489
BBX	BRAT1	ENSAPLP00000029376	ENSAPLP00000002781	BBX high mobility group box domain containing.	BRCA1 associated ATM activator 1.	0.586
BBX	BSX	ENSAPLP00000029376	ENSAPLP00000024842	BBX high mobility group box domain containing.	Brain specific homeobox.	0.480
BBX	IL17RD	ENSAPLP00000029376	ENSAPLP00000002440	BBX high mobility group box domain containing.	Interleukin 17 receptor D.	0.447
BBX	LAP3	ENSAPLP00000029376	ENSAPLP00000007097	BBX high mobility group box domain containing.	Leucine aminopeptidase 3.	0.453
BBX	PCSK9	ENSAPLP00000029376	ENSAPLP00000004259	BBX high mobility group box domain containing.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.450
BBX	SCUBE3	ENSAPLP00000029376	ENSAPLP00000005709	BBX high mobility group box domain containing.	Signal peptide, CUB domain and EGF like domain containing 3.	0.484
BBX	SIN3B	ENSAPLP00000029376	ENSAPLP00000011546	BBX high mobility group box domain containing.	SIN3 transcription regulator family member B.	0.447
BRAT1	BBX	ENSAPLP00000002781	ENSAPLP00000029376	BRCA1 associated ATM activator 1.	BBX high mobility group box domain containing.	0.586
BRAT1	SCUBE3	ENSAPLP00000002781	ENSAPLP00000005709	BRCA1 associated ATM activator 1.	Signal peptide, CUB domain and EGF like domain containing 3.	0.524
BSX	BBX	ENSAPLP00000024842	ENSAPLP00000029376	Brain specific homeobox.	BBX high mobility group box domain containing.	0.480
IL17RD	BBX	ENSAPLP00000002440	ENSAPLP00000029376	Interleukin 17 receptor D.	BBX high mobility group box domain containing.	0.447
IL17RD	LAP3	ENSAPLP00000002440	ENSAPLP00000007097	Interleukin 17 receptor D.	Leucine aminopeptidase 3.	0.447

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.945

expected number of edges:

16

PPI enrichment p-value:

0.00486

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

7 of 22

1.85

3.37

4.32e-09

GO:0034660

ncRNA metabolic process

8 of 90

1.3

1.79

1.65e-07

GO:0010467

Gene expression

8 of 212

0.93

0.91

3.36e-05

GO:0019538

Protein metabolic process

8 of 217

0.92

0.9

3.72e-05

GO:0044281

Small molecule metabolic process

8 of 370

0.69

0.54

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

7 of 23

1.83

3.37

3.08e-09

GO:0000049

tRNA binding

5 of 26

1.63

2.04

8.55e-06

GO:0002161

aminoacyl-tRNA editing activity

2 of 8

1.75

0.86

0.0201

GO:0005524

ATP binding

8 of 294

0.79

0.67

0.00040

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

10 of 923

0.39

0.27

0.0350

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23606477

(2013) Genomes of the class Erysipelotrichia clarify the firmicute origin of the class Mollicutes.

4 of 11

1.91

2.31

1.07e-05

PMID:37932270

(2023) Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts.

2 of 4

2.05

1.2

0.0051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:445

Mixed, incl. PDZ domain, and Alditol phosphate metabolic process

4 of 5

2.25

2.68

5.56e-06

CL:328

Aminoacyl-tRNA synthetase

5 of 18

1.79

2.3

5.56e-06

CL:330

Aminoacyl-tRNA synthetase

4 of 11

1.91

2.08

4.03e-05

CL:72

Peptide biosynthetic process, and Coiled coil

10 of 198

1.05

1.3

8.36e-08

CL:334

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

2 of 5

1.95

0.88

0.0213

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

7 of 30

1.72

3.1

2.87e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

7 of 21

1.87

3.66

5.98e-10

KW-0648

Protein biosynthesis

7 of 46

1.53

2.42

3.76e-08

KW-0820

tRNA-binding

4 of 15

1.78

2.03

2.80e-05

KW-0862

Zinc

4 of 45

1.3

1.13

0.00089

KW-0963

Cytoplasm

8 of 214

0.92

2.13e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 5

2.13

1.5

0.0013

PF08264

Anticodon-binding domain of tRNA ligase

2 of 3

2.17

0.8

0.0327

PF01588

Putative tRNA binding domain

2 of 3

2.17

0.8

0.0327

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045864

Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

4 of 14

1.81

1.53

0.00064

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 6

2.05

1.33

0.0028

IPR012340

Nucleic acid-binding, OB-fold

4 of 33

1.43

1.02

0.0044

IPR018163

Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily

2 of 2

2.35

0.85

0.0275

IPR012947

Threonyl/alanyl tRNA synthetase, SAD

2 of 2

2.35

0.85

0.0275

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 2

2.35

1.09

0.0098

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