ENSAPLP00000029499 protein (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

ENSAPLP00000029499

Uncharacterized protein. (163 aa)

Predicted Functional Partners:

NTNG2

0.917

NTNG1

0.915

DCC

0.619

IGDCC4

0.619

NEO1

0.619

IGDCC3

0.619

FNDC1

0.566

MDGA1

0.521

LRRC4C

0.400

DRAXIN

0.400

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCC	DRAXIN	ENSAPLP00000009157	ENSAPLP00000009304	DCC netrin 1 receptor.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	0.748
DCC	ENSAPLP00000029499	ENSAPLP00000009157	ENSAPLP00000029499	DCC netrin 1 receptor.	Uncharacterized protein.	0.619
DCC	NTNG1	ENSAPLP00000009157	ENSAPLP00000004740	DCC netrin 1 receptor.	Netrin G1.	0.660
DCC	NTNG2	ENSAPLP00000009157	ENSAPLP00000016020	DCC netrin 1 receptor.	Netrin G2.	0.619
DRAXIN	DCC	ENSAPLP00000009304	ENSAPLP00000009157	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	DCC netrin 1 receptor.	0.748
DRAXIN	ENSAPLP00000029499	ENSAPLP00000009304	ENSAPLP00000029499	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	Uncharacterized protein.	0.400
DRAXIN	IGDCC3	ENSAPLP00000009304	ENSAPLP00000015994	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	Immunoglobulin superfamily DCC subclass member 3.	0.518
DRAXIN	IGDCC4	ENSAPLP00000009304	ENSAPLP00000012961	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	Immunoglobulin superfamily DCC subclass member 4.	0.541
DRAXIN	NEO1	ENSAPLP00000009304	ENSAPLP00000015653	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	Neogenin 1.	0.878
DRAXIN	NTNG1	ENSAPLP00000009304	ENSAPLP00000004740	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	Netrin G1.	0.447
DRAXIN	NTNG2	ENSAPLP00000009304	ENSAPLP00000016020	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	Netrin G2.	0.400
ENSAPLP00000029499	DCC	ENSAPLP00000029499	ENSAPLP00000009157	Uncharacterized protein.	DCC netrin 1 receptor.	0.619
ENSAPLP00000029499	DRAXIN	ENSAPLP00000029499	ENSAPLP00000009304	Uncharacterized protein.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	0.400
ENSAPLP00000029499	FNDC1	ENSAPLP00000029499	ENSAPLP00000004948	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.566
ENSAPLP00000029499	IGDCC3	ENSAPLP00000029499	ENSAPLP00000015994	Uncharacterized protein.	Immunoglobulin superfamily DCC subclass member 3.	0.619
ENSAPLP00000029499	IGDCC4	ENSAPLP00000029499	ENSAPLP00000012961	Uncharacterized protein.	Immunoglobulin superfamily DCC subclass member 4.	0.619
ENSAPLP00000029499	LRRC4C	ENSAPLP00000029499	ENSAPLP00000000867	Uncharacterized protein.	Leucine rich repeat containing 4C.	0.400
ENSAPLP00000029499	MDGA1	ENSAPLP00000029499	ENSAPLP00000029635	Uncharacterized protein.	MAM domain containing glycosylphosphatidylinositol anchor 1.	0.521
ENSAPLP00000029499	NEO1	ENSAPLP00000029499	ENSAPLP00000015653	Uncharacterized protein.	Neogenin 1.	0.619
ENSAPLP00000029499	NTNG1	ENSAPLP00000029499	ENSAPLP00000004740	Uncharacterized protein.	Netrin G1.	0.915

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.531

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

4 of 146

1.62

0.85

0.0181

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019888

Protein phosphatase regulator activity

5 of 61

2.09

2.89

1.02e-06

GO:0030234

Enzyme regulator activity

6 of 929

0.99

0.67

0.0100

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005963

Magnesium-dependent protein serine/threonine phosphatase complex

5 of 21

2.56

4.37

3.78e-09

GO:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.84

6.22e-08

GO:0140535

Intracellular protein-containing complex

6 of 610

1.17

1.12

0.00026

GO:1902494

Catalytic complex

6 of 1194

0.88

0.6

0.0104

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17552

Protein phosphatase type 2A complex, and ERKs are inactivated

7 of 16

2.82

7.49

4.28e-15

CL:17555

Protein phosphatase type 2A complex, and Serine/Threonine protein phosphatase PP2A-like

5 of 10

2.88

5.46

6.04e-11

CL:17557

Protein phosphatase 2A regulatory subunit PR55, and Serine/Threonine protein phosphatase PP2A-like

2 of 5

2.78

1.38

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla04114

Oocyte meiosis

6 of 81

2.05

3.94

1.29e-09

apla03015

mRNA surveillance pathway

5 of 45

2.22

3.91

7.57e-09

apla04261

Adrenergic signaling in cardiomyocytes

5 of 81

1.97

3.17

8.21e-08

apla04350

TGF-beta signaling pathway

3 of 72

1.8

1.54

0.00059

apla04136

Autophagy - other

2 of 19

2.2

1.35

0.0028

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389513

CTLA4 inhibitory signaling

6 of 23

2.6

5.58

1.24e-11

MAP-196299

Beta-catenin phosphorylation cascade

5 of 12

2.8

5.15

2.07e-10

MAP-195253

Degradation of beta-catenin by the destruction complex

6 of 44

2.31

4.68

2.07e-10

MAP-388841

Costimulation by the CD28 family

6 of 72

2.1

3.99

1.66e-09

MAP-68882

Mitotic Anaphase

7 of 210

1.7

3.0

5.15e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.68

1.27e-07

GOCC:0008287

Protein serine/threonine phosphatase complex

5 of 44

2.23

3.4

1.27e-07

GOCC:1902494

Catalytic complex

9 of 1192

1.06

1.23

9.68e-07

GOCC:0032991

Protein-containing complex

10 of 3780

0.6

0.48

0.0010

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01603

Protein phosphatase 2A regulatory B subunit (B56 family)

3 of 4

3.05

2.66

1.47e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002554

Protein phosphatase 2A, regulatory B subunit, B56

3 of 4

3.05

2.39

4.57e-05

IPR047129

Serine/Threonine protein phosphatase PP2A-like

2 of 4

2.88

0.97

0.0176

IPR011989

Armadillo-like helical

4 of 192

1.5

0.83

0.0176

IPR006186

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

2 of 12

2.4

0.75

0.0438

IPR016024

Armadillo-type fold

4 of 280

1.33

0.65

0.0380

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00156

Protein phosphatase 2A homologues, catalytic domain.

2 of 11

2.44

0.9

0.0225

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