CDKN1A-2 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CDKN1A-2

Uncharacterized protein. (182 aa)

Predicted Functional Partners:

SKP2

0.979

CCNE1

0.977

CCNE2

0.976

CCNA1

0.967

CUL1

0.967

CDK6

0.967

SKP1

0.966

CCND1

0.957

CCND2

0.952

CCND3

0.952

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNA1	CCNE1	ENSAPLP00000009517	ENSAPLP00000013590	Cyclin A1; Belongs to the cyclin family.	Cyclin E1; Belongs to the cyclin family.	0.858
CCNA1	CCNE2	ENSAPLP00000009517	ENSAPLP00000007297	Cyclin A1; Belongs to the cyclin family.	Cyclin E2; Belongs to the cyclin family.	0.738
CCNA1	CDK6	ENSAPLP00000009517	ENSAPLP00000021367	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.985
CCNA1	CDKN1A-2	ENSAPLP00000009517	ENSAPLP00000031755	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.967
CCNA1	CUL1	ENSAPLP00000009517	ENSAPLP00000020847	Cyclin A1; Belongs to the cyclin family.	Cullin 1; Belongs to the cullin family.	0.841
CCNA1	SKP1	ENSAPLP00000009517	ENSAPLP00000014996	Cyclin A1; Belongs to the cyclin family.	S-phase kinase associated protein 1; Belongs to the SKP1 family.	0.901
CCNA1	SKP2	ENSAPLP00000009517	ENSAPLP00000017755	Cyclin A1; Belongs to the cyclin family.	S-phase kinase associated protein 2.	0.939
CCND1	CCND2	ENSAPLP00000019210	ENSAPLP00000002462	Cyclin_C domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.912
CCND1	CCND3	ENSAPLP00000019210	ENSAPLP00000032237	Cyclin_C domain-containing protein.	Cyclin_C domain-containing protein; Belongs to the cyclin family.	0.922
CCND1	CCNE1	ENSAPLP00000019210	ENSAPLP00000013590	Cyclin_C domain-containing protein.	Cyclin E1; Belongs to the cyclin family.	0.591
CCND1	CCNE2	ENSAPLP00000019210	ENSAPLP00000007297	Cyclin_C domain-containing protein.	Cyclin E2; Belongs to the cyclin family.	0.460
CCND1	CDK6	ENSAPLP00000019210	ENSAPLP00000021367	Cyclin_C domain-containing protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.998
CCND1	CDKN1A-2	ENSAPLP00000019210	ENSAPLP00000031755	Cyclin_C domain-containing protein.	Uncharacterized protein.	0.957
CCND1	CUL1	ENSAPLP00000019210	ENSAPLP00000020847	Cyclin_C domain-containing protein.	Cullin 1; Belongs to the cullin family.	0.606
CCND1	SKP1	ENSAPLP00000019210	ENSAPLP00000014996	Cyclin_C domain-containing protein.	S-phase kinase associated protein 1; Belongs to the SKP1 family.	0.730
CCND1	SKP2	ENSAPLP00000019210	ENSAPLP00000017755	Cyclin_C domain-containing protein.	S-phase kinase associated protein 2.	0.718
CCND2	CCND1	ENSAPLP00000002462	ENSAPLP00000019210	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin_C domain-containing protein.	0.912
CCND2	CCND3	ENSAPLP00000002462	ENSAPLP00000032237	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin_C domain-containing protein; Belongs to the cyclin family.	0.922
CCND2	CCNE2	ENSAPLP00000002462	ENSAPLP00000007297	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin E2; Belongs to the cyclin family.	0.410
CCND2	CDK6	ENSAPLP00000002462	ENSAPLP00000021367	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.991

page 1 of 6

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.531

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

4 of 146

1.62

0.85

0.0181

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019888

Protein phosphatase regulator activity

5 of 61

2.09

2.89

1.02e-06

GO:0030234

Enzyme regulator activity

6 of 929

0.99

0.67

0.0100

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005963

Magnesium-dependent protein serine/threonine phosphatase complex

5 of 21

2.56

4.37

3.78e-09

GO:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.84

6.22e-08

GO:0140535

Intracellular protein-containing complex

6 of 610

1.17

1.12

0.00026

GO:1902494

Catalytic complex

6 of 1194

0.88

0.6

0.0104

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17552

Protein phosphatase type 2A complex, and ERKs are inactivated

7 of 16

2.82

7.49

4.28e-15

CL:17555

Protein phosphatase type 2A complex, and Serine/Threonine protein phosphatase PP2A-like

5 of 10

2.88

5.46

6.04e-11

CL:17557

Protein phosphatase 2A regulatory subunit PR55, and Serine/Threonine protein phosphatase PP2A-like

2 of 5

2.78

1.38

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla04114

Oocyte meiosis

6 of 81

2.05

3.94

1.29e-09

apla03015

mRNA surveillance pathway

5 of 45

2.22

3.91

7.57e-09

apla04261

Adrenergic signaling in cardiomyocytes

5 of 81

1.97

3.17

8.21e-08

apla04350

TGF-beta signaling pathway

3 of 72

1.8

1.54

0.00059

apla04136

Autophagy - other

2 of 19

2.2

1.35

0.0028

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389513

CTLA4 inhibitory signaling

6 of 23

2.6

5.58

1.24e-11

MAP-196299

Beta-catenin phosphorylation cascade

5 of 12

2.8

5.15

2.07e-10

MAP-195253

Degradation of beta-catenin by the destruction complex

6 of 44

2.31

4.68

2.07e-10

MAP-388841

Costimulation by the CD28 family

6 of 72

2.1

3.99

1.66e-09

MAP-68882

Mitotic Anaphase

7 of 210

1.7

3.0

5.15e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.68

1.27e-07

GOCC:0008287

Protein serine/threonine phosphatase complex

5 of 44

2.23

3.4

1.27e-07

GOCC:1902494

Catalytic complex

9 of 1192

1.06

1.23

9.68e-07

GOCC:0032991

Protein-containing complex

10 of 3780

0.6

0.48

0.0010

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01603

Protein phosphatase 2A regulatory B subunit (B56 family)

3 of 4

3.05

2.66

1.47e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002554

Protein phosphatase 2A, regulatory B subunit, B56

3 of 4

3.05

2.39

4.57e-05

IPR047129

Serine/Threonine protein phosphatase PP2A-like

2 of 4

2.88

0.97

0.0176

IPR011989

Armadillo-like helical

4 of 192

1.5

0.83

0.0176

IPR006186

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

2 of 12

2.4

0.75

0.0438

IPR016024

Armadillo-type fold

4 of 280

1.33

0.65

0.0380

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00156

Protein phosphatase 2A homologues, catalytic domain.

2 of 11

2.44

0.9

0.0225

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (12%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About