ENSAPLP00000031947 protein (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ENSAPLP00000031947

Uncharacterized protein. (91 aa)

Predicted Functional Partners:

PEX10

0.573

PEX13

0.572

CRYL1

0.565

HADH

0.565

ACOT8

0.522

TYSND1

0.520

SCP2

0.508

PEX5

0.487

ENSAPLP00000020216

0.487

PEX5L

0.474

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT8	CRYL1	ENSAPLP00000024105	ENSAPLP00000001940	Uncharacterized protein.	Crystallin lambda 1.	0.565
ACOT8	ENSAPLP00000020216	ENSAPLP00000024105	ENSAPLP00000020216	Uncharacterized protein.	Uncharacterized protein.	0.487
ACOT8	ENSAPLP00000031947	ENSAPLP00000024105	ENSAPLP00000031947	Uncharacterized protein.	Uncharacterized protein.	0.522
ACOT8	HADH	ENSAPLP00000024105	ENSAPLP00000007044	Uncharacterized protein.	Hydroxyacyl-CoA dehydrogenase.	0.565
ACOT8	PEX10	ENSAPLP00000024105	ENSAPLP00000009116	Uncharacterized protein.	Peroxisomal biogenesis factor 10.	0.573
ACOT8	PEX13	ENSAPLP00000024105	ENSAPLP00000005837	Uncharacterized protein.	Peroxisomal biogenesis factor 13.	0.572
ACOT8	PEX5	ENSAPLP00000024105	ENSAPLP00000007675	Uncharacterized protein.	Peroxisomal biogenesis factor 5.	0.487
ACOT8	PEX5L	ENSAPLP00000024105	ENSAPLP00000010931	Uncharacterized protein.	Peroxisomal biogenesis factor 5 like.	0.474
ACOT8	SCP2	ENSAPLP00000024105	ENSAPLP00000007864	Uncharacterized protein.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.948
ACOT8	TYSND1	ENSAPLP00000024105	ENSAPLP00000025172	Uncharacterized protein.	Trypsin domain containing 1.	0.520
CRYL1	ACOT8	ENSAPLP00000001940	ENSAPLP00000024105	Crystallin lambda 1.	Uncharacterized protein.	0.565
CRYL1	ENSAPLP00000031947	ENSAPLP00000001940	ENSAPLP00000031947	Crystallin lambda 1.	Uncharacterized protein.	0.565
CRYL1	SCP2	ENSAPLP00000001940	ENSAPLP00000007864	Crystallin lambda 1.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.887
ENSAPLP00000020216	ACOT8	ENSAPLP00000020216	ENSAPLP00000024105	Uncharacterized protein.	Uncharacterized protein.	0.487
ENSAPLP00000020216	ENSAPLP00000031947	ENSAPLP00000020216	ENSAPLP00000031947	Uncharacterized protein.	Uncharacterized protein.	0.487
ENSAPLP00000020216	PEX10	ENSAPLP00000020216	ENSAPLP00000009116	Uncharacterized protein.	Peroxisomal biogenesis factor 10.	0.883
ENSAPLP00000020216	PEX13	ENSAPLP00000020216	ENSAPLP00000005837	Uncharacterized protein.	Peroxisomal biogenesis factor 13.	0.934
ENSAPLP00000020216	SCP2	ENSAPLP00000020216	ENSAPLP00000007864	Uncharacterized protein.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.992
ENSAPLP00000020216	TYSND1	ENSAPLP00000020216	ENSAPLP00000025172	Uncharacterized protein.	Trypsin domain containing 1.	0.622
ENSAPLP00000031947	ACOT8	ENSAPLP00000031947	ENSAPLP00000024105	Uncharacterized protein.	Uncharacterized protein.	0.522

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.836

expected number of edges:

13

PPI enrichment p-value:

0.0148

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010498

Proteasomal protein catabolic process

11 of 152

2.0

6.44

3.47e-19

GO:0006511

Ubiquitin-dependent protein catabolic process

7 of 230

1.63

2.71

1.69e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004298

Threonine-type endopeptidase activity

2 of 3

2.97

1.23

0.0059

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005839

Proteasome core complex

11 of 14

3.04

14.89

1.04e-29

GO:0019773

Proteasome core complex, alpha-subunit complex

6 of 7

3.08

7.69

4.75e-15

GO:0019774

Proteasome core complex, beta-subunit complex

5 of 7

3.0

6.12

4.21e-12

GO:0005634

Nucleus

11 of 2154

0.85

0.94

2.80e-08

GO:0005737

Cytoplasm

11 of 5000

0.49

0.42

0.00022

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3435

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 29

2.72

12.39

1.87e-26

CL:3467

Proteasome core complex

7 of 10

2.99

8.67

4.03e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 42

2.56

11.56

3.67e-26

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-187577

SCF(Skp2)-mediated degradation of p27/p21

10 of 35

2.6

10.62

2.84e-23

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

10 of 36

2.59

10.56

3.03e-23

MAP-1236975

Antigen processing-Cross presentation

10 of 37

2.58

10.5

3.29e-23

MAP-174178

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

11 of 54

2.45

10.35

2.60e-24

MAP-9755511

KEAP1-NFE2L2 pathway

11 of 57

2.43

10.23

2.60e-24

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005839

Proteasome core complex

11 of 14

3.04

14.83

1.37e-29

GOCC:0019773

Proteasome core complex, alpha-subunit complex

6 of 7

3.08

7.59

7.49e-15

GOCC:0019774

Proteasome core complex, beta-subunit complex

5 of 7

3.0

6.03

6.31e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0888

Threonine protease

9 of 11

3.06

11.94

1.59e-23

KW-0647

Proteasome

8 of 11

3.01

10.36

1.83e-20

KW-0963

Cytoplasm

9 of 122

2.01

5.73

5.51e-16

KW-0539

Nucleus

9 of 297

1.63

3.47

1.05e-12

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00227

Proteasome subunit

11 of 15

3.01

14.56

3.35e-29

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001353

Proteasome, subunit alpha/beta

11 of 15

3.01

14.36

9.30e-29

IPR029055

Nucleophile aminohydrolases, N-terminal

11 of 23

2.82

13.2

1.72e-27

IPR023332

Proteasome alpha-type subunit

6 of 7

3.08

7.17

4.88e-14

IPR000426

Proteasome alpha-subunit, N-terminal domain

6 of 7

3.08

7.17

4.88e-14

IPR023333

Proteasome B-type subunit

5 of 8

2.94

5.51

5.62e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00948

Proteasome subunit A N-terminal signature Add an annotation

6 of 7

3.08

7.43

1.53e-14

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