F2RL1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F2RL1

F2R like trypsin receptor 1. (399 aa)

Predicted Functional Partners:

F2RL3

0.938

F2RL2

0.911

PARD3

0.901

F2

0.872

U3IA97_ANAPP

0.698

ENSAPLP00000027915

0.698

U3I913_ANAPP

0.697

U3I9W7_ANAPP

0.696

ENSAPLP00000017420

0.696

PRR16

0.586

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000017420	F2RL1	ENSAPLP00000017420	ENSAPLP00000032014	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	F2R like trypsin receptor 1.	0.696
ENSAPLP00000017420	F2RL2	ENSAPLP00000017420	ENSAPLP00000003994	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II thrombin receptor like 2.	0.677
ENSAPLP00000017420	F2RL3	ENSAPLP00000017420	ENSAPLP00000011879	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.733
ENSAPLP00000017420	PARD3	ENSAPLP00000017420	ENSAPLP00000003012	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Par-3 family cell polarity regulator.	0.650
ENSAPLP00000017420	U3I9W7_ANAPP	ENSAPLP00000017420	ENSAPLP00000004038	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.903
ENSAPLP00000027915	F2RL1	ENSAPLP00000027915	ENSAPLP00000032014	Peptidase S1 domain-containing protein.	F2R like trypsin receptor 1.	0.698
ENSAPLP00000027915	F2RL2	ENSAPLP00000027915	ENSAPLP00000003994	Peptidase S1 domain-containing protein.	Coagulation factor II thrombin receptor like 2.	0.677
ENSAPLP00000027915	F2RL3	ENSAPLP00000027915	ENSAPLP00000011879	Peptidase S1 domain-containing protein.	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.739
ENSAPLP00000027915	PARD3	ENSAPLP00000027915	ENSAPLP00000003012	Peptidase S1 domain-containing protein.	Par-3 family cell polarity regulator.	0.650
F2	F2RL1	ENSAPLP00000013537	ENSAPLP00000032014	Uncharacterized protein; Belongs to the peptidase S1 family.	F2R like trypsin receptor 1.	0.872
F2	F2RL2	ENSAPLP00000013537	ENSAPLP00000003994	Uncharacterized protein; Belongs to the peptidase S1 family.	Coagulation factor II thrombin receptor like 2.	0.840
F2	F2RL3	ENSAPLP00000013537	ENSAPLP00000011879	Uncharacterized protein; Belongs to the peptidase S1 family.	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.972
F2	PARD3	ENSAPLP00000013537	ENSAPLP00000003012	Uncharacterized protein; Belongs to the peptidase S1 family.	Par-3 family cell polarity regulator.	0.650
F2RL1	ENSAPLP00000017420	ENSAPLP00000032014	ENSAPLP00000017420	F2R like trypsin receptor 1.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.696
F2RL1	ENSAPLP00000027915	ENSAPLP00000032014	ENSAPLP00000027915	F2R like trypsin receptor 1.	Peptidase S1 domain-containing protein.	0.698
F2RL1	F2	ENSAPLP00000032014	ENSAPLP00000013537	F2R like trypsin receptor 1.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.872
F2RL1	F2RL2	ENSAPLP00000032014	ENSAPLP00000003994	F2R like trypsin receptor 1.	Coagulation factor II thrombin receptor like 2.	0.911
F2RL1	F2RL3	ENSAPLP00000032014	ENSAPLP00000011879	F2R like trypsin receptor 1.	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.938
F2RL1	PARD3	ENSAPLP00000032014	ENSAPLP00000003012	F2R like trypsin receptor 1.	Par-3 family cell polarity regulator.	0.901
F2RL1	PRR16	ENSAPLP00000032014	ENSAPLP00000007578	F2R like trypsin receptor 1.	Proline rich 16.	0.586

page 1 of 4

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13177

Mixed, incl. dUTPase, and APOBEC/CMP deaminase, zinc-binding

2 of 5

3.01

1.5

0.0060

CL:12016

Cytochrome b5, heme-binding site, and MOSC domain

2 of 5

3.01

1.5

0.0060

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0349

Heme

2 of 32

2.2

1.35

0.0080

KW-0560

Oxidoreductase

3 of 173

1.65

1.22

0.0065

KW-0274

FAD

2 of 54

1.98

1.15

0.0146

KW-0808

Transferase

3 of 434

1.25

0.84

0.0165

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00970

Oxidoreductase FAD-binding domain

2 of 6

2.93

1.6

0.0043

PF00175

Oxidoreductase NAD-binding domain

2 of 11

2.67

1.48

0.0060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018506

Cytochrome b5, heme-binding site

2 of 4

3.11

1.49

0.0064

IPR008333

Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

2 of 6

2.93

1.48

0.0064

IPR001834

NADH:cytochrome b5 reductase-like

2 of 5

3.01

1.48

0.0064

IPR001709

Flavoprotein pyridine nucleotide cytochrome reductase

2 of 9

2.75

1.47

0.0064

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 13

2.6

1.45

0.0067

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 10

2.71

1.68

0.0030

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About