KIF3C protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

KIF3C

Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (738 aa)

Predicted Functional Partners:

KIF1A

0.921

ENSAPLP00000024104

0.918

KIF3A

0.900

KIFAP3

0.900

IFT52

0.724

IFT57

0.649

IFT46

0.636

IFT80

0.610

SFT2D2

0.602

IFT88

0.596

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000024104	KIF1A	ENSAPLP00000024104	ENSAPLP00000027849	Uncharacterized protein.	PH domain-containing protein.	0.934
ENSAPLP00000024104	KIF3A	ENSAPLP00000024104	ENSAPLP00000011440	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.921
ENSAPLP00000024104	KIF3C	ENSAPLP00000024104	ENSAPLP00000032461	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.918
IFT46	IFT52	ENSAPLP00000005142	ENSAPLP00000005276	Intraflagellar transport 46.	Intraflagellar transport 52.	0.993
IFT46	IFT57	ENSAPLP00000005142	ENSAPLP00000005266	Intraflagellar transport 46.	Intraflagellar transport 57.	0.992
IFT46	IFT80	ENSAPLP00000005142	ENSAPLP00000024502	Intraflagellar transport 46.	Intraflagellar transport 80.	0.987
IFT46	IFT88	ENSAPLP00000005142	ENSAPLP00000002243	Intraflagellar transport 46.	Intraflagellar transport 88.	0.987
IFT46	KIF3A	ENSAPLP00000005142	ENSAPLP00000011440	Intraflagellar transport 46.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.548
IFT46	KIF3C	ENSAPLP00000005142	ENSAPLP00000032461	Intraflagellar transport 46.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.636
IFT46	KIFAP3	ENSAPLP00000005142	ENSAPLP00000027595	Intraflagellar transport 46.	Kinesin associated protein 3.	0.637
IFT52	IFT46	ENSAPLP00000005276	ENSAPLP00000005142	Intraflagellar transport 52.	Intraflagellar transport 46.	0.993
IFT52	IFT57	ENSAPLP00000005276	ENSAPLP00000005266	Intraflagellar transport 52.	Intraflagellar transport 57.	0.997
IFT52	IFT80	ENSAPLP00000005276	ENSAPLP00000024502	Intraflagellar transport 52.	Intraflagellar transport 80.	0.993
IFT52	IFT88	ENSAPLP00000005276	ENSAPLP00000002243	Intraflagellar transport 52.	Intraflagellar transport 88.	0.997
IFT52	KIF3A	ENSAPLP00000005276	ENSAPLP00000011440	Intraflagellar transport 52.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.765
IFT52	KIF3C	ENSAPLP00000005276	ENSAPLP00000032461	Intraflagellar transport 52.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.724
IFT52	KIFAP3	ENSAPLP00000005276	ENSAPLP00000027595	Intraflagellar transport 52.	Kinesin associated protein 3.	0.783
IFT57	IFT46	ENSAPLP00000005266	ENSAPLP00000005142	Intraflagellar transport 57.	Intraflagellar transport 46.	0.992
IFT57	IFT52	ENSAPLP00000005266	ENSAPLP00000005276	Intraflagellar transport 57.	Intraflagellar transport 52.	0.997
IFT57	IFT80	ENSAPLP00000005266	ENSAPLP00000024502	Intraflagellar transport 57.	Intraflagellar transport 80.	0.996

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.863

expected number of edges:

12

PPI enrichment p-value:

0.000464

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033108

Mitochondrial respiratory chain complex assembly

7 of 47

1.95

3.64

2.62e-09

GO:0033617

Mitochondrial cytochrome c oxidase assembly

5 of 29

2.01

2.69

2.00e-06

GO:0007005

Mitochondrion organization

9 of 274

1.29

1.84

5.45e-08

GO:0065003

Protein-containing complex assembly

8 of 488

0.99

0.95

0.00011

GO:0016043

Cellular component organization

10 of 1889

0.5

0.35

0.0153

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005507

Copper ion binding

4 of 22

2.04

1.91

0.00015

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

9 of 69

1.89

4.65

1.55e-13

GO:0005740

Mitochondrial envelope

10 of 466

1.11

1.46

1.23e-08

GO:0005743

Mitochondrial inner membrane

5 of 269

1.05

0.78

0.0042

GO:0031966

Mitochondrial membrane

6 of 422

0.93

0.72

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33498264

(2021) Regulation of COX Assembly and Function by Twin CX9C Proteins-Implications for Human Disease.

6 of 16

2.35

3.81

2.66e-08

PMID:18761382

(2009) Redox regulation of protein folding in the mitochondrial intermembrane space.

6 of 34

2.02

2.89

6.77e-07

PMID:28886682

(2017) Copper Acquisition and Utilization in Fungi.

6 of 36

2.0

2.86

6.77e-07

PMID:34557489

(2021) Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.

6 of 47

1.88

2.56

2.01e-06

PMID:29495437

(2018) The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants.

5 of 25

2.08

2.44

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2974

Respiratory chain complex IV assembly, and Heme a metabolic process

9 of 18

2.48

8.1

5.75e-18

CL:2995

Mixed, incl. CHCH domain, and Cytochrome c oxidase biogenesis protein Cmc1 like

4 of 6

2.6

3.49

2.57e-07

CL:2977

Copper chaperone activity, and Cytochrome oxidase c subunit VIb

3 of 5

2.56

2.32

4.72e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 59

1.91

4.21

1.45e-11

GOCC:1902695

Metallochaperone complex

3 of 4

2.65

2.52

2.12e-05

GOCC:0005740

Mitochondrial envelope

9 of 368

1.17

1.52

1.20e-07

GOCC:0005739

Mitochondrion

10 of 851

0.85

0.87

2.70e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

8 of 97

1.69

3.31

1.73e-10

KW-0186

Copper

4 of 27

1.95

2.29

1.50e-05

KW-0496

Mitochondrion

10 of 807

0.87

0.91

1.36e-06

KW-0999

Mitochondrion inner membrane

4 of 213

1.05

0.6

0.0273

KW-0143

Chaperone

3 of 105

1.23

0.6

0.0448

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08583

Cytochrome c oxidase biogenesis protein Cmc1 like

2 of 2

2.78

1.06

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013892

Cytochrome c oxidase biogenesis protein Cmc1-like

2 of 2

2.78

0.78

0.0390

IPR009069

Cysteine alpha-hairpin motif superfamily

2 of 3

2.6

0.78

0.0390

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