STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (245 aa)    
Predicted Functional Partners:
U3IPC5_ANAPP
SMC_N domain-containing protein.
    
 0.998
NSMCE1
NSE1 homolog, SMC5-SMC6 complex component.
    
 0.998
SMC6
Structural maintenance of chromosomes 6.
    
 0.998
NSMCE4A
Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
    
 0.997
PRAM1
hSH3 domain-containing protein.
    
 0.985
UBE2I
Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.921
SMC3
Structural maintenance of chromosomes protein.
    
 0.891
KCTD2
Potassium channel tetramerization domain containing 2.
   
 0.882
SMC1B
Structural maintenance of chromosomes protein.
    
 0.860
SUMO2
Small ubiquitin-related modifier.
   
 0.857
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.