STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGA24955.1Dihydrofolate reductase; PFAM: RibD C-terminal domain. (182 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.827
AGA31134.1
Hypothetical protein; PFAM: Activator of Hsp90 ATPase homolog 1-like protein.
 
     0.505
AGA24956.1
Hypothetical protein.
  
    0.462
AGA27171.1
PFAM: Prolyl oligopeptidase family.
  
     0.455
AGA28110.1
Hypothetical protein.
 
  
 0.443
AGA31189.1
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; PFAM: Acyltransferase; AMP-binding enzyme; Major Facilitator Superfamily; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases.
  
 
 0.440
AGA25866.1
PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II.
     
 0.434
AGA24954.1
Hypothetical protein.
       0.418
AGA26414.1
Polyketide synthase family protein; PFAM: Phosphopantetheine attachment site; Acyl transferase domain; KR domain; Alcohol dehydrogenase GroES-like domain; Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; Zinc-binding dehydrogenase.
  
  
 0.410
AGA26234.1
Hypothetical protein; PFAM: Activator of Hsp90 ATPase homolog 1-like protein.
 
     0.409
Your Current Organism:
Singulisphaera acidiphila
NCBI taxonomy Id: 886293
Other names: S. acidiphila DSM 18658, Singulisphaera acidiphila DSM 18658, Singulisphaera acidiphila MOB10, Singulisphaera acidiphila str. DSM 18658, Singulisphaera acidiphila strain DSM 18658
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.