STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AGA26098.1O-6-methylguanine DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (181 aa)    
Predicted Functional Partners:
AGA27283.1
Uncharacterized Fe-S protein; PFAM: Domain of unknown function (DUF1730); TIGRFAM: iron-sulfur cluster binding protein, putative.
      0.710
AGA26990.1
PFAM: Metal binding domain of Ada; 6-O-methylguanine DNA methyltransferase, DNA binding domain; TIGRFAM: O-6-methylguanine DNA methyltransferase.
 
  
0.528
mntH
Natural resistance-associated macrophage protein metal ion transporter NRAMP; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family.
  
    0.444
AGA26190.1
PFAM: MgsA AAA+ ATPase C terminal; Holliday junction DNA helicase ruvB N-terminus.
 
     0.429
AGA27565.1
A/G-specific adenine glycosylase; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif; TIGRFAM: A/G-specific adenine glycosylase.
 
   
 0.407
AGA26099.1
Putative RND superfamily drug exporter; PFAM: MMPL family.
       0.400
Your Current Organism:
Singulisphaera acidiphila
NCBI taxonomy Id: 886293
Other names: S. acidiphila DSM 18658, Singulisphaera acidiphila DSM 18658, Singulisphaera acidiphila MOB10, Singulisphaera acidiphila str. DSM 18658, Singulisphaera acidiphila strain DSM 18658
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.