STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGA27750.1Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: Sugar-specific transcriptional regulator TrmB; O-methyltransferase. (340 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I, bacterial; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removi [...]
  
  
 0.799
AGA29023.1
PFAM: Restriction endonuclease.
   
    0.775
AGA27913.1
Fe-S-cluster-containing hydrogenase subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
   
  
 0.575
AGA29123.1
PFAM: 4Fe-4S binding domain; Cyclic nucleotide-binding domain.
   
    0.572
AGA29878.1
Fe-S-cluster-containing hydrogenase subunit; PFAM: DMSO reductase anchor subunit (DmsC).
   
    0.572
AGA27751.1
Putative hydrolase or acyltransferase of alpha/beta superfamily.
       0.454
AGA25970.1
PFAM: Magnesium chelatase, subunit ChlI; von Willebrand factor type A domain.
 
   
 0.412
AGA24516.1
Isoform II.
  
     0.402
AGA31109.1
Amino acid adenylation enzyme/thioester reductase family protein; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; KR domain; Beta-ketoacyl synthase, N-terminal domain; Condensation domain; AMP-binding enzyme; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: amino acid adenylation domain.
  
  
 0.401
Your Current Organism:
Singulisphaera acidiphila
NCBI taxonomy Id: 886293
Other names: S. acidiphila DSM 18658, Singulisphaera acidiphila DSM 18658, Singulisphaera acidiphila MOB10, Singulisphaera acidiphila str. DSM 18658, Singulisphaera acidiphila strain DSM 18658
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.