STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucBDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa)    
Predicted Functional Partners:
lpdA
Dihydrolipoyl dehydrogenase; COG: COG1249.
 0.999
sucA
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component; COG: COG0567.
 0.999
lpdA-2
Dihydrolipoyl dehydrogenase; COG: COG1249.
0.997
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.985
sucD
succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.978
EFV96152.1
acyl-CoA dehydrogenase, C-terminal domain protein; COG: COG1960.
   
 0.913
Lpd3
Pyridine nucleotide-disulfide oxidoreductase; COG: COG1249.
 0.907
aceE
Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 
 0.868
Gor
Putative glutathione-disulfide reductase; COG: COG1249.
 0.864
YhcM
ATPase, AFG1 family; COG: COG1485.
 
    0.819
Your Current Organism:
Lautropia mirabilis
NCBI taxonomy Id: 887898
Other names: L. mirabilis ATCC 51599, Lautropia mirabilis ATCC 51599, Lautropia mirabilis str. ATCC 51599, Lautropia mirabilis strain ATCC 51599
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