EFV94911.1 protein (Lautropia mirabilis) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

EFV94911.1

GDSL-like protein. (556 aa)

Predicted Functional Partners:

EFV94912.1

0.567

npdA

0.545

PpsE

0.524

EFV95095.1

0.522

AzoB

0.477

apaH

0.424

EFV94159.1

0.424

carB

0.413

carA

0.413

Your Current Organism:

Lautropia mirabilis

NCBI taxonomy Id: 887898
Other names: L. mirabilis ATCC 51599, Lautropia mirabilis ATCC 51599, Lautropia mirabilis str. ATCC 51599, Lautropia mirabilis strain ATCC 51599

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AzoB	EFV94911.1	HMPREF0551_0913	HMPREF0551_1328	NmrA family protein.	GDSL-like protein.	0.477
AzoB	EFV95095.1	HMPREF0551_0913	HMPREF0551_1053	NmrA family protein.	Tannase and feruloyl esterase.	0.684
AzoB	PpsE	HMPREF0551_0913	HMPREF0551_1039	NmrA family protein.	AMP-binding enzyme; COG: COG3321.	0.804
EFV94159.1	EFV94911.1	HMPREF0551_2274	HMPREF0551_1328	ABC transporter, solute-binding protein.	GDSL-like protein.	0.424
EFV94159.1	EFV95095.1	HMPREF0551_2274	HMPREF0551_1053	ABC transporter, solute-binding protein.	Tannase and feruloyl esterase.	0.666
EFV94911.1	AzoB	HMPREF0551_1328	HMPREF0551_0913	GDSL-like protein.	NmrA family protein.	0.477
EFV94911.1	EFV94159.1	HMPREF0551_1328	HMPREF0551_2274	GDSL-like protein.	ABC transporter, solute-binding protein.	0.424
EFV94911.1	EFV94912.1	HMPREF0551_1328	HMPREF0551_1329	GDSL-like protein.	Hypothetical protein.	0.567
EFV94911.1	EFV95095.1	HMPREF0551_1328	HMPREF0551_1053	GDSL-like protein.	Tannase and feruloyl esterase.	0.522
EFV94911.1	PpsE	HMPREF0551_1328	HMPREF0551_1039	GDSL-like protein.	AMP-binding enzyme; COG: COG3321.	0.524
EFV94911.1	apaH	HMPREF0551_1328	HMPREF0551_0055	GDSL-like protein.	Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.	0.424
EFV94911.1	carA	HMPREF0551_1328	HMPREF0551_1326	GDSL-like protein.	Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Belongs to the CarA family.	0.413
EFV94911.1	carB	HMPREF0551_1328	HMPREF0551_1325	GDSL-like protein.	Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family.	0.413
EFV94911.1	npdA	HMPREF0551_1328	HMPREF0551_1327	GDSL-like protein.	NAD-dependent deacetylase; COG: COG0846; Belongs to the sirtuin family. Class III subfamily.	0.545
EFV94912.1	EFV94911.1	HMPREF0551_1329	HMPREF0551_1328	Hypothetical protein.	GDSL-like protein.	0.567
EFV94912.1	npdA	HMPREF0551_1329	HMPREF0551_1327	Hypothetical protein.	NAD-dependent deacetylase; COG: COG0846; Belongs to the sirtuin family. Class III subfamily.	0.410
EFV95095.1	AzoB	HMPREF0551_1053	HMPREF0551_0913	Tannase and feruloyl esterase.	NmrA family protein.	0.684
EFV95095.1	EFV94159.1	HMPREF0551_1053	HMPREF0551_2274	Tannase and feruloyl esterase.	ABC transporter, solute-binding protein.	0.666
EFV95095.1	EFV94911.1	HMPREF0551_1053	HMPREF0551_1328	Tannase and feruloyl esterase.	GDSL-like protein.	0.522
EFV95095.1	PpsE	HMPREF0551_1053	HMPREF0551_1039	Tannase and feruloyl esterase.	AMP-binding enzyme; COG: COG3321.	0.405

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006914

Autophagy

7 of 78

1.92

3.58

2.43e-09

GO:0030242

Autophagy of peroxisome

3 of 4

2.84

2.43

3.66e-05

GO:0016236

Macroautophagy

4 of 39

1.97

2.01

7.51e-05

GO:0015031

Protein transport

6 of 431

1.11

0.96

0.00079

GO:0006810

Transport

9 of 1132

0.86

0.8

8.39e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

4 of 4

2.96

4.01

4.19e-08

GO:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

4 of 4

2.96

4.01

4.19e-08

GO:0005770

Late endosome

4 of 41

1.95

2.36

9.70e-06

GO:0005768

Endosome

6 of 160

1.54

2.16

7.62e-07

GO:0031410

Cytoplasmic vesicle

8 of 297

1.39

2.08

4.19e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11291

Autophagy - other, and SNARE complex assembly

8 of 34

2.33

6.44

1.03e-14

CL:11297

Autophagy, and Phosphatidylinositol 3-kinase complex, class III, type I

5 of 14

2.52

4.53

1.45e-09

CL:8217

Mixed, incl. HOPS complex, and VPS9 domain

3 of 29

1.98

1.57

0.00075

CL:11299

Ubiquitin-like autophagy protein Apg12 , and Autophagy

2 of 7

2.42

1.22

0.0056

CL:8218

HOPS complex, and phosphatidylinositol-5-phosphate binding

2 of 18

2.01

0.84

0.0265

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

5 of 38

2.08

3.37

5.96e-08

map04138

Autophagy - yeast

6 of 97

1.75

2.85

5.96e-08

map04145

Phagosome

3 of 81

1.53

1.08

0.0041

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9612973

Autophagy

7 of 78

1.92

3.75

6.84e-10

MAP-1632852

Macroautophagy

7 of 78

1.92

3.75

6.84e-10

MAP-1483255

PI Metabolism

4 of 36

2.01

2.27

2.10e-05

MAP-5668599

RHO GTPases Activate NADPH Oxidases

3 of 11

2.4

2.17

8.02e-05

MAP-1660517

Synthesis of PIPs at the late endosome membrane

3 of 11

2.4

2.17

8.02e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

5 of 6

2.88

5.16

2.39e-10

GOCC:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

4 of 4

2.96

4.28

1.31e-08

GOCC:0044232

Organelle membrane contact site

3 of 25

2.04

1.75

0.00034

GOCC:0000421

Autophagosome membrane

2 of 4

2.66

1.53

0.0016

GOCC:0071561

Nucleus-vacuole junction

2 of 5

2.57

1.47

0.0020

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

2 of 2

2.96

1.58

0.0014

KW-0072

Autophagy

2 of 14

2.12

0.98

0.0144

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04110

Ubiquitin-like autophagy protein Apg12

2 of 3

2.79

1.1

0.0100

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045162

Serine/threonine-protein kinase Vps15-like

2 of 2

2.96

0.98

0.0172

IPR004241

Autophagy protein Atg8 ubiquitin-like

2 of 2

2.96

0.98

0.0172

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