STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (684 aa)    
Predicted Functional Partners:
EFV01630.1
HRDC domain protein.
  
 0.999
EFV01106.1
Single-strand binding family protein; COG: COG0629.
  
 
 0.995
leuS
leucine--tRNA ligase; COG: COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.972
nifJ
Pyruvate synthase; COG: COG0674.
  
   0.949
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.940
nifJ-2
Pyruvate synthase; COG: COG0674.
  
   0.934
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.887
hslU
ATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.
  
  
 0.878
hslV
ATP-dependent protease HslVU, peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
  
  
 0.857
rpsB
Ribosomal protein S2; COG: COG0052; Belongs to the universal ribosomal protein uS2 family.
  
  
 0.842
Your Current Organism:
Pseudoramibacter alactolyticus
NCBI taxonomy Id: 887929
Other names: P. alactolyticus ATCC 23263, Pseudoramibacter alactolyticus ATCC 23263, Pseudoramibacter alactolyticus str. ATCC 23263, Pseudoramibacter alactolyticus strain ATCC 23263
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