node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clpB | dnaJ | HMPREF9004_0661 | HMPREF9004_0668 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone DnaJ; COG: COG0484. | 0.765 |
clpB | dnaJ2 | HMPREF9004_0661 | HMPREF9004_1688 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.765 |
clpB | dnaK | HMPREF9004_0661 | HMPREF9004_0670 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
clpB | groEL | HMPREF9004_0661 | HMPREF9004_0616 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.675 |
clpB | groES | HMPREF9004_0661 | HMPREF9004_0445 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.689 |
clpB | grpE | HMPREF9004_0661 | HMPREF9004_0669 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.859 |
clpB | hrcA | HMPREF9004_0661 | HMPREF9004_1689 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.635 |
clpB | hscA | HMPREF9004_0661 | HMPREF9004_1405 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone HscA; COG: COG0443; Belongs to the heat shock protein 70 family. | 0.955 |
clpB | hspR | HMPREF9004_0661 | HMPREF9004_0667 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock regulator protein HspR; COG: COG0789. | 0.443 |
clpC | dnaJ | HMPREF9004_1180 | HMPREF9004_0668 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone DnaJ; COG: COG0484. | 0.765 |
clpC | dnaJ2 | HMPREF9004_1180 | HMPREF9004_1688 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.765 |
clpC | dnaK | HMPREF9004_1180 | HMPREF9004_0670 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
clpC | groEL | HMPREF9004_1180 | HMPREF9004_0616 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.675 |
clpC | groES | HMPREF9004_1180 | HMPREF9004_0445 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.689 |
clpC | grpE | HMPREF9004_1180 | HMPREF9004_0669 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.859 |
clpC | hrcA | HMPREF9004_1180 | HMPREF9004_1689 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.635 |
clpC | hscA | HMPREF9004_1180 | HMPREF9004_1405 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone HscA; COG: COG0443; Belongs to the heat shock protein 70 family. | 0.955 |
clpC | hspR | HMPREF9004_1180 | HMPREF9004_0667 | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | Heat shock regulator protein HspR; COG: COG0789. | 0.443 |
dnaJ | clpB | HMPREF9004_0668 | HMPREF9004_0661 | Chaperone DnaJ; COG: COG0484. | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.765 |
dnaJ | clpC | HMPREF9004_0668 | HMPREF9004_1180 | Chaperone DnaJ; COG: COG0484. | ATP-dependent Clp protease ATP-binding subunit ClpC; COG: COG0542; Belongs to the ClpA/ClpB family. | 0.765 |