node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENO18255.1 | thiD | HMPREF9004_0824 | HMPREF9004_0825 | Thiaminase; COG: COG0819. | Phosphomethylpyrimidine kinase; COG: COG0351. | 0.999 |
ENO18255.1 | thiE | HMPREF9004_0824 | HMPREF9004_0826 | Thiaminase; COG: COG0819. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.993 |
ENO18255.1 | thiF | HMPREF9004_0824 | HMPREF9004_1057 | Thiaminase; COG: COG0819. | Thiazole biosynthesis adenylyltransferase ThiF; COG: COG0476. | 0.447 |
ENO18255.1 | thiL | HMPREF9004_0824 | HMPREF9004_0097 | Thiaminase; COG: COG0819. | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.496 |
ENO18255.1 | thiM | HMPREF9004_0824 | HMPREF9004_0827 | Thiaminase; COG: COG0819. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.994 |
guaB2 | purM | HMPREF9004_0439 | HMPREF9004_0744 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole synthetase; COG: COG0150. | 0.772 |
guaB2 | thiD | HMPREF9004_0439 | HMPREF9004_0825 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphomethylpyrimidine kinase; COG: COG0351. | 0.623 |
guaB2 | thiE | HMPREF9004_0439 | HMPREF9004_0826 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.459 |
guaB2 | thiF | HMPREF9004_0439 | HMPREF9004_1057 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Thiazole biosynthesis adenylyltransferase ThiF; COG: COG0476. | 0.782 |
pdxS | pdxT | HMPREF9004_1499 | HMPREF9004_1498 | Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.999 |
pdxS | thiD | HMPREF9004_1499 | HMPREF9004_0825 | Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Phosphomethylpyrimidine kinase; COG: COG0351. | 0.923 |
pdxT | pdxS | HMPREF9004_1498 | HMPREF9004_1499 | Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.999 |
pdxT | thiD | HMPREF9004_1498 | HMPREF9004_0825 | Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Phosphomethylpyrimidine kinase; COG: COG0351. | 0.921 |
purM | guaB2 | HMPREF9004_0744 | HMPREF9004_0439 | Phosphoribosylaminoimidazole synthetase; COG: COG0150. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.772 |
purM | thiD | HMPREF9004_0744 | HMPREF9004_0825 | Phosphoribosylaminoimidazole synthetase; COG: COG0150. | Phosphomethylpyrimidine kinase; COG: COG0351. | 0.639 |
rsgA | thiD | HMPREF9004_0273 | HMPREF9004_0825 | GTPase EngC; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | Phosphomethylpyrimidine kinase; COG: COG0351. | 0.823 |
rsgA | thiE | HMPREF9004_0273 | HMPREF9004_0826 | GTPase EngC; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.890 |
rsgA | thiL | HMPREF9004_0273 | HMPREF9004_0097 | GTPase EngC; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.926 |
thiD | ENO18255.1 | HMPREF9004_0825 | HMPREF9004_0824 | Phosphomethylpyrimidine kinase; COG: COG0351. | Thiaminase; COG: COG0819. | 0.999 |
thiD | guaB2 | HMPREF9004_0825 | HMPREF9004_0439 | Phosphomethylpyrimidine kinase; COG: COG0351. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.623 |