node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENO18711.1 | relA | HMPREF9004_0381 | HMPREF9004_1490 | ppx/GppA family phosphatase; COG: COG0248. | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.926 |
gmk | ndk | HMPREF9004_1384 | HMPREF9004_0035 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.971 |
gmk | pyk | HMPREF9004_1384 | HMPREF9004_1468 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | 0.930 |
gmk | relA | HMPREF9004_1384 | HMPREF9004_1490 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.925 |
mtrB | ndk | HMPREF9004_0289 | HMPREF9004_0035 | Sensor histidine kinase; COG: COG0642. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.916 |
mtrB | pyk | HMPREF9004_0289 | HMPREF9004_1468 | Sensor histidine kinase; COG: COG0642. | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | 0.907 |
mtrB | relA | HMPREF9004_0289 | HMPREF9004_1490 | Sensor histidine kinase; COG: COG0642. | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.925 |
ndk | gmk | HMPREF9004_0035 | HMPREF9004_1384 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.971 |
ndk | mtrB | HMPREF9004_0035 | HMPREF9004_0289 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Sensor histidine kinase; COG: COG0642. | 0.916 |
ndk | pyk | HMPREF9004_0035 | HMPREF9004_1468 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | 0.912 |
ndk | relA | HMPREF9004_0035 | HMPREF9004_1490 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.957 |
ndk | rplE | HMPREF9004_0035 | HMPREF9004_0502 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. | 0.651 |
ndk | rplF | HMPREF9004_0035 | HMPREF9004_0499 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.718 |
ndk | rplO | HMPREF9004_0035 | HMPREF9004_0495 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.913 |
ndk | rpsN | HMPREF9004_0035 | HMPREF9004_0501 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. | 0.993 |
ndk | rpsO | HMPREF9004_0035 | HMPREF9004_0196 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.996 |
pyk | gmk | HMPREF9004_1468 | HMPREF9004_1384 | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.930 |
pyk | mtrB | HMPREF9004_1468 | HMPREF9004_0289 | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | Sensor histidine kinase; COG: COG0642. | 0.907 |
pyk | ndk | HMPREF9004_1468 | HMPREF9004_0035 | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.912 |
pyk | relA | HMPREF9004_1468 | HMPREF9004_1490 | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.921 |