node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENO17584.1 | ENO18336.1 | HMPREF9004_1494 | HMPREF9004_0905 | Hypothetical protein. | Hypothetical protein; COG: COG0706. | 0.934 |
ENO17584.1 | ffh | HMPREF9004_1494 | HMPREF9004_1577 | Hypothetical protein. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.941 |
ENO17584.1 | ftsY | HMPREF9004_1494 | HMPREF9004_1578 | Hypothetical protein. | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.942 |
ENO17584.1 | secA | HMPREF9004_1494 | HMPREF9004_0284 | Hypothetical protein. | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.941 |
ENO17584.1 | secE | HMPREF9004_1494 | HMPREF9004_1287 | Hypothetical protein. | Hypothetical protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.961 |
ENO17584.1 | secG2 | HMPREF9004_1494 | HMPREF9004_1435 | Hypothetical protein. | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.947 |
ENO17584.1 | secY | HMPREF9004_1494 | HMPREF9004_0494 | Hypothetical protein. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.947 |
ENO18336.1 | ENO17584.1 | HMPREF9004_0905 | HMPREF9004_1494 | Hypothetical protein; COG: COG0706. | Hypothetical protein. | 0.934 |
ENO18336.1 | ffh | HMPREF9004_0905 | HMPREF9004_1577 | Hypothetical protein; COG: COG0706. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.960 |
ENO18336.1 | ftsY | HMPREF9004_0905 | HMPREF9004_1578 | Hypothetical protein; COG: COG0706. | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.945 |
ENO18336.1 | rplC | HMPREF9004_0905 | HMPREF9004_0516 | Hypothetical protein; COG: COG0706. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.719 |
ENO18336.1 | rplO | HMPREF9004_0905 | HMPREF9004_0495 | Hypothetical protein; COG: COG0706. | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.582 |
ENO18336.1 | secA | HMPREF9004_0905 | HMPREF9004_0284 | Hypothetical protein; COG: COG0706. | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.960 |
ENO18336.1 | secE | HMPREF9004_0905 | HMPREF9004_1287 | Hypothetical protein; COG: COG0706. | Hypothetical protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.982 |
ENO18336.1 | secG2 | HMPREF9004_0905 | HMPREF9004_1435 | Hypothetical protein; COG: COG0706. | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.986 |
ENO18336.1 | secY | HMPREF9004_0905 | HMPREF9004_0494 | Hypothetical protein; COG: COG0706. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.992 |
ffh | ENO17584.1 | HMPREF9004_1577 | HMPREF9004_1494 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Hypothetical protein. | 0.941 |
ffh | ENO18336.1 | HMPREF9004_1577 | HMPREF9004_0905 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Hypothetical protein; COG: COG0706. | 0.960 |
ffh | ftsY | HMPREF9004_1577 | HMPREF9004_1578 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.999 |
ffh | rplC | HMPREF9004_1577 | HMPREF9004_0516 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.972 |