node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENO17677.1 | dhs | HMPREF9004_1587 | HMPREF9004_1584 | DNA polymerase III; COG: COG2176. | 3-deoxy-7-phosphoheptulonate synthase; COG: COG3200; Belongs to the class-II DAHP synthase family. | 0.427 |
ENO17677.1 | pfp | HMPREF9004_1587 | HMPREF9004_1585 | DNA polymerase III; COG: COG2176. | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. | 0.426 |
ENO17677.1 | plsC2 | HMPREF9004_1587 | HMPREF9004_1586 | DNA polymerase III; COG: COG2176. | 1-acylglycerol-3-phosphate O-acyltransferase; COG: COG0204. | 0.579 |
ENO17801.1 | aroB | HMPREF9004_1711 | HMPREF9004_1373 | Chorismate mutase; COG: COG1605. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.933 |
ENO17801.1 | aroC | HMPREF9004_1711 | HMPREF9004_1372 | Chorismate mutase; COG: COG1605. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.985 |
ENO17801.1 | aroE | HMPREF9004_1711 | HMPREF9004_1473 | Chorismate mutase; COG: COG1605. | Shikimate dehydrogenase; COG: COG0169; Belongs to the shikimate dehydrogenase family. | 0.632 |
ENO17801.1 | aroK | HMPREF9004_1711 | HMPREF9004_1374 | Chorismate mutase; COG: COG1605. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.933 |
ENO17801.1 | dhs | HMPREF9004_1711 | HMPREF9004_1584 | Chorismate mutase; COG: COG1605. | 3-deoxy-7-phosphoheptulonate synthase; COG: COG3200; Belongs to the class-II DAHP synthase family. | 0.946 |
ENO17801.1 | tkt | HMPREF9004_1711 | HMPREF9004_1430 | Chorismate mutase; COG: COG1605. | Transketolase; COG: COG0021; Belongs to the transketolase family. | 0.525 |
aroB | ENO17801.1 | HMPREF9004_1373 | HMPREF9004_1711 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Chorismate mutase; COG: COG1605. | 0.933 |
aroB | aroC | HMPREF9004_1373 | HMPREF9004_1372 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.998 |
aroB | aroE | HMPREF9004_1373 | HMPREF9004_1473 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Shikimate dehydrogenase; COG: COG0169; Belongs to the shikimate dehydrogenase family. | 0.998 |
aroB | aroK | HMPREF9004_1373 | HMPREF9004_1374 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.999 |
aroB | dhs | HMPREF9004_1373 | HMPREF9004_1584 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 3-deoxy-7-phosphoheptulonate synthase; COG: COG3200; Belongs to the class-II DAHP synthase family. | 0.974 |
aroB | tkt | HMPREF9004_1373 | HMPREF9004_1430 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Transketolase; COG: COG0021; Belongs to the transketolase family. | 0.483 |
aroC | ENO17801.1 | HMPREF9004_1372 | HMPREF9004_1711 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase; COG: COG1605. | 0.985 |
aroC | aroB | HMPREF9004_1372 | HMPREF9004_1373 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.998 |
aroC | aroE | HMPREF9004_1372 | HMPREF9004_1473 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Shikimate dehydrogenase; COG: COG0169; Belongs to the shikimate dehydrogenase family. | 0.983 |
aroC | aroK | HMPREF9004_1372 | HMPREF9004_1374 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.998 |
aroC | dhs | HMPREF9004_1372 | HMPREF9004_1584 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 3-deoxy-7-phosphoheptulonate synthase; COG: COG3200; Belongs to the class-II DAHP synthase family. | 0.434 |