STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (210 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease III; COG: COG0708.
 
 0.999
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
 
  
 0.891
mutY
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
 
 
0.807
EGK59877.1
Glycerol-3-phosphate dehydrogenase; COG: COG2848.
       0.798
EGK59878.1
ACT domain protein; COG: COG3830; Belongs to the UPF0237 family.
       0.795
argHA
Argininosuccinate lyase/amino-acid N-acetyltransferase; COG: COG1246; Belongs to the acetyltransferase family.
     
 0.778
tyrA
Prephenate dehydrogenase; COG: COG0287.
       0.727
aroF
3-deoxy-7-phosphoheptulonate synthase; COG: COG2876.
       0.707
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.623
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
   
 
  0.623
Your Current Organism:
Centipeda periodontii
NCBI taxonomy Id: 888060
Other names: C. periodontii DSM 2778, Centipeda periodontii ATCC 35019, Centipeda periodontii DSM 2778, Centipeda periodontii str. DSM 2778, Centipeda periodontii strain DSM 2778
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