APR76580.1 protein (Minicystis rosea) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

APR76580.1

Serine/threonine kinase PKN8. (485 aa)

Predicted Functional Partners:

APR75151.1

0.691

APR76581.1

0.565

APR85767.1

0.514

APR79766.1

0.469

APR82608.1

0.438

APR74982.1

0.409

Your Current Organism:

Minicystis rosea

NCBI taxonomy Id: 888845
Other names: DSM 24000, M. rosea, Minicystis rosea Garcia et al. 2014, NCCB 100349, Sorangiineae bacterium SBNa008, strain SBNa008

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APR74982.1	APR76580.1	A7982_00328	A7982_01927	Adenylate cyclase.	Serine/threonine kinase PKN8.	0.409
APR74982.1	APR79766.1	A7982_00328	A7982_05113	Adenylate cyclase.	Serine/threonine protein kinase.	0.741
APR75151.1	APR76580.1	A7982_00497	A7982_01927	Serine/threonine protein kinase.	Serine/threonine kinase PKN8.	0.691
APR76580.1	APR74982.1	A7982_01927	A7982_00328	Serine/threonine kinase PKN8.	Adenylate cyclase.	0.409
APR76580.1	APR75151.1	A7982_01927	A7982_00497	Serine/threonine kinase PKN8.	Serine/threonine protein kinase.	0.691
APR76580.1	APR76581.1	A7982_01927	A7982_01928	Serine/threonine kinase PKN8.	Hypothetical protein.	0.565
APR76580.1	APR79766.1	A7982_01927	A7982_05113	Serine/threonine kinase PKN8.	Serine/threonine protein kinase.	0.469
APR76580.1	APR82608.1	A7982_01927	A7982_07957	Serine/threonine kinase PKN8.	Serine/threonine protein kinase.	0.438
APR76580.1	APR85767.1	A7982_01927	A7982_11116	Serine/threonine kinase PKN8.	Serine/threonine protein kinase.	0.514
APR76581.1	APR76580.1	A7982_01928	A7982_01927	Hypothetical protein.	Serine/threonine kinase PKN8.	0.565
APR79766.1	APR74982.1	A7982_05113	A7982_00328	Serine/threonine protein kinase.	Adenylate cyclase.	0.741
APR79766.1	APR76580.1	A7982_05113	A7982_01927	Serine/threonine protein kinase.	Serine/threonine kinase PKN8.	0.469
APR82608.1	APR76580.1	A7982_07957	A7982_01927	Serine/threonine protein kinase.	Serine/threonine kinase PKN8.	0.438
APR85767.1	APR76580.1	A7982_11116	A7982_01927	Serine/threonine protein kinase.	Serine/threonine kinase PKN8.	0.514

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.889

expected number of edges:

10

PPI enrichment p-value:

0.107

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008360

Regulation of cell shape

8 of 21

2.05

4.82

2.51e-12

GO:0051301

Cell division

8 of 24

1.99

4.65

2.51e-12

GO:0009252

Peptidoglycan biosynthetic process

7 of 20

2.01

4.27

6.90e-11

GO:0007049

Cell cycle

5 of 18

1.91

2.88

2.98e-07

GO:0071555

Cell wall organization

5 of 22

1.82

2.65

6.38e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

4 of 11

2.02

2.12

5.01e-05

GO:0008955

Peptidoglycan glycosyltransferase activity

2 of 3

2.29

0.95

0.0178

GO:0008658

Penicillin binding

2 of 5

2.07

0.83

0.0279

GO:0043168

Anion binding

6 of 370

0.67

0.41

0.0343

GO:0036094

Small molecule binding

6 of 409

0.63

0.37

0.0458

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:598

Cell division, and Penicillin-binding Protein dimerisation domain

11 of 23

2.14

7.51

2.09e-20

CL:599

Cell cycle, and D-Alanine metabolism

8 of 17

2.14

5.53

1.07e-13

CL:600

Peptidoglycan synthesis, and PASTA domain

7 of 12

2.23

5.25

3.19e-12

CL:603

Mur ligase, C-terminal, and Lipid modification

5 of 6

2.39

4.06

8.41e-09

CL:633

Regulation of cell shape

3 of 5

2.24

1.98

0.00016

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

7 of 25

1.91

3.92

1.59e-10

map00471

D-Glutamine and D-glutamate metabolism

2 of 4

2.16

1.11

0.0082

map01502

Vancomycin resistance

2 of 9

1.81

0.88

0.0198

map00300

Lysine biosynthesis

2 of 12

1.69

0.81

0.0244

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

3 of 8

2.04

1.5

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0133

Cell shape

6 of 12

2.16

4.18

9.68e-10

KW-0132

Cell division

6 of 17

2.01

3.76

2.61e-09

KW-0131

Cell cycle

6 of 17

2.01

3.76

2.61e-09

KW-0961

Cell wall biogenesis/degradation

5 of 11

2.12

3.54

3.04e-08

KW-0573

Peptidoglycan synthesis

5 of 11

2.12

3.54

3.04e-08

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

4 of 5

2.37

2.81

3.89e-06

PF08245

Mur ligase middle domain

4 of 6

2.29

2.77

3.89e-06

PF01225

Mur ligase family, catalytic domain

3 of 4

2.34

2.03

0.00014

PF03717

Penicillin-binding Protein dimerisation domain

2 of 2

2.46

1.18

0.0067

PF01098

Cell cycle protein

2 of 2

2.46

1.18

0.0067

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004101

Mur ligase, C-terminal

4 of 5

2.37

2.61

9.67e-06

IPR036615

Mur ligase, C-terminal domain superfamily

4 of 6

2.29

2.58

9.67e-06

IPR036565

Mur-like, catalytic domain superfamily

4 of 6

2.29

2.58

9.67e-06

IPR013221

Mur ligase, central

4 of 6

2.29

2.58

9.67e-06

IPR000713

Mur ligase, N-terminal catalytic domain

3 of 4

2.34

1.94

0.00022

(more ...)

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