APR78058.1 protein (Minicystis rosea) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

APR78058.1

ThiJ/PfpI family protein. (300 aa)

Predicted Functional Partners:

tpx

0.640

APR85452.1

0.600

APR82853.1

0.574

APR77276.1

0.573

APR78059.1

0.568

APR80468.1

0.536

APR86432.1

0.535

APR81039.1

0.477

APR83913.1

0.477

APR75940.1

0.457

Your Current Organism:

Minicystis rosea

NCBI taxonomy Id: 888845
Other names: DSM 24000, M. rosea, Minicystis rosea Garcia et al. 2014, NCCB 100349, Sorangiineae bacterium SBNa008, strain SBNa008

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APR75940.1	APR78058.1	A7982_01287	A7982_03405	2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.	ThiJ/PfpI family protein.	0.457
APR75940.1	APR86432.1	A7982_01287	A7982_11781	2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.	Osmotically inducible protein.	0.483
APR77276.1	APR78058.1	A7982_02623	A7982_03405	Superoxide dismutase.	ThiJ/PfpI family protein.	0.573
APR77276.1	APR86432.1	A7982_02623	A7982_11781	Superoxide dismutase.	Osmotically inducible protein.	0.461
APR78058.1	APR75940.1	A7982_03405	A7982_01287	ThiJ/PfpI family protein.	2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.	0.457
APR78058.1	APR77276.1	A7982_03405	A7982_02623	ThiJ/PfpI family protein.	Superoxide dismutase.	0.573
APR78058.1	APR78059.1	A7982_03405	A7982_03406	ThiJ/PfpI family protein.	Serine esterase, putative.	0.568
APR78058.1	APR80468.1	A7982_03405	A7982_05815	ThiJ/PfpI family protein.	DNA topoisomerase IB (poxvirus type).	0.536
APR78058.1	APR81039.1	A7982_03405	A7982_06386	ThiJ/PfpI family protein.	Succinate dehydrogenase iron-sulfur protein.	0.477
APR78058.1	APR82853.1	A7982_03405	A7982_08202	ThiJ/PfpI family protein.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.574
APR78058.1	APR83913.1	A7982_03405	A7982_09262	ThiJ/PfpI family protein.	Succinate dehydrogenase iron-sulfur protein.	0.477
APR78058.1	APR85452.1	A7982_03405	A7982_10801	ThiJ/PfpI family protein.	General stress protein.	0.600
APR78058.1	APR86432.1	A7982_03405	A7982_11781	ThiJ/PfpI family protein.	Osmotically inducible protein.	0.535
APR78058.1	tpx	A7982_03405	A7982_00704	ThiJ/PfpI family protein.	Thiol peroxidase, Tpx-type; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily.	0.640
APR78059.1	APR78058.1	A7982_03406	A7982_03405	Serine esterase, putative.	ThiJ/PfpI family protein.	0.568
APR80468.1	APR78058.1	A7982_05815	A7982_03405	DNA topoisomerase IB (poxvirus type).	ThiJ/PfpI family protein.	0.536
APR80468.1	APR85452.1	A7982_05815	A7982_10801	DNA topoisomerase IB (poxvirus type).	General stress protein.	0.471
APR80468.1	APR86432.1	A7982_05815	A7982_11781	DNA topoisomerase IB (poxvirus type).	Osmotically inducible protein.	0.469
APR81039.1	APR78058.1	A7982_06386	A7982_03405	Succinate dehydrogenase iron-sulfur protein.	ThiJ/PfpI family protein.	0.477
APR81039.1	APR83913.1	A7982_06386	A7982_09262	Succinate dehydrogenase iron-sulfur protein.	Succinate dehydrogenase iron-sulfur protein.	0.912

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Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0532

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

8 of 106

2.4

7.29

1.31e-15

GO:0048015

Phosphatidylinositol-mediated signaling

4 of 15

2.95

4.64

8.97e-09

GO:0046856

Phosphatidylinositol dephosphorylation

4 of 32

2.62

3.94

9.52e-08

GO:0030242

Autophagy of peroxisome

3 of 6

3.22

3.69

5.25e-07

GO:0000045

Autophagosome assembly

3 of 37

2.43

2.49

3.80e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0052744

Phosphatidylinositol monophosphate phosphatase activity

4 of 5

3.43

5.29

1.02e-09

GO:0052742

Phosphatidylinositol kinase activity

4 of 17

2.9

4.38

2.42e-08

GO:0043812

phosphatidylinositol-4-phosphate phosphatase activity

3 of 3

3.52

3.89

2.70e-07

GO:0016303

1-phosphatidylinositol-3-kinase activity

3 of 3

3.52

3.89

2.70e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

3 of 5

3.3

3.58

8.56e-07

GO:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

3 of 5

3.3

3.58

8.56e-07

GO:0000407

Phagophore assembly site

3 of 36

2.44

2.56

2.78e-05

GO:0005777

Peroxisome

3 of 262

1.58

1.12

0.0050

GO:0031410

Cytoplasmic vesicle

4 of 764

1.24

0.93

0.0050

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:38744

PI Metabolism, and Phosphoinositide phospholipase C family

6 of 66

2.48

5.54

3.47e-11

CL:38734

Inositol phosphate metabolism, and Copine, C-terminal

7 of 144

2.21

5.2

1.36e-11

CL:38762

Mixed, incl. Phosphatidylinositol-4-phosphate 5-kinase, and Phosphatidylinositol kinase

4 of 17

2.9

4.47

1.72e-08

CL:38766

Phosphatidylinositol kinase, and phosphatidylinositol-4-phosphate phosphatase activity

2 of 5

3.13

1.86

0.00070

CL:38840

Synthesis of PIPs at the late endosome membrane

2 of 17

2.59

1.33

0.0053

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00562

Inositol phosphate metabolism

8 of 142

2.27

7.05

4.45e-16

map04070

Phosphatidylinositol signaling system

8 of 153

2.24

6.92

4.45e-16

map04136

Autophagy - other

3 of 54

2.27

2.49

2.80e-05

map04145

Phagosome

3 of 162

1.79

1.64

0.00052

map01100

Metabolic pathways

8 of 6496

0.61

0.49

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5668599

RHO GTPases Activate NADPH Oxidases

3 of 4

3.4

4.05

1.35e-07

MAP-1660514

Synthesis of PIPs at the Golgi membrane

4 of 33

2.61

4.01

6.76e-08

MAP-1483255

PI Metabolism

5 of 95

2.24

3.83

3.82e-08

MAP-1483257

Phospholipid metabolism

6 of 315

1.8

3.07

4.82e-08

MAP-1660517

Synthesis of PIPs at the late endosome membrane

3 of 19

2.72

3.06

4.75e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

3 of 12

2.92

2.89

1.12e-05

GOCC:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

3 of 12

2.92

2.89

1.12e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02383

SacI homology domain

3 of 10

3.0

2.89

1.15e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001263

Phosphoinositide 3-kinase, accessory (PIK) domain

3 of 5

3.3

3.07

6.31e-06

IPR042236

Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

3 of 6

3.22

3.06

6.31e-06

IPR015433

Phosphatidylinositol kinase

3 of 6

3.22

3.06

6.31e-06

IPR002013

SAC domain

3 of 11

2.96

2.92

1.02e-05

IPR018936

Phosphatidylinositol 3/4-kinase, conserved site

2 of 8

2.92

1.39

0.0044

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00145

Phosphoinositide 3-kinase family, accessory domain (PIK domain)

2 of 3

3.35

2.03

0.00038

SM00146

Phosphoinositide 3-kinase, catalytic domain

2 of 8

2.92

1.8

0.00086

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