APR83072.1 protein (Minicystis rosea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

APR83072.1

N-acetylneuraminate synthase. (310 aa)

Predicted Functional Partners:

APR83071.1

0.995

APR83066.1

0.963

APR83070.1

0.947

APR83069.1

0.927

APR83067.1

0.817

APR83068.1

0.798

APR83065.1

0.696

APR83073.1

0.655

APR75746.1

0.627

APR83811.1

0.613

Your Current Organism:

Minicystis rosea

NCBI taxonomy Id: 888845
Other names: DSM 24000, M. rosea, Minicystis rosea Garcia et al. 2014, NCCB 100349, Sorangiineae bacterium SBNa008, strain SBNa008

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APR75746.1	APR83072.1	A7982_01092	A7982_08421	Hydroxymethylglutaryl-CoA lyase.	N-acetylneuraminate synthase.	0.627
APR83065.1	APR83066.1	A7982_08414	A7982_08415	Hypothetical protein.	N-Acetylneuraminate cytidylyltransferase.	0.839
APR83065.1	APR83067.1	A7982_08414	A7982_08416	Hypothetical protein.	Transketolase.	0.638
APR83065.1	APR83068.1	A7982_08414	A7982_08417	Hypothetical protein.	Transketolase.	0.638
APR83065.1	APR83069.1	A7982_08414	A7982_08418	Hypothetical protein.	Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.578
APR83065.1	APR83070.1	A7982_08414	A7982_08419	Hypothetical protein.	3-oxoacyl-[acyl-carrier protein] reductase.	0.557
APR83065.1	APR83071.1	A7982_08414	A7982_08420	Hypothetical protein.	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase.	0.581
APR83065.1	APR83072.1	A7982_08414	A7982_08421	Hypothetical protein.	N-acetylneuraminate synthase.	0.696
APR83065.1	APR83811.1	A7982_08414	A7982_09160	Hypothetical protein.	dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.545
APR83066.1	APR83065.1	A7982_08415	A7982_08414	N-Acetylneuraminate cytidylyltransferase.	Hypothetical protein.	0.839
APR83066.1	APR83067.1	A7982_08415	A7982_08416	N-Acetylneuraminate cytidylyltransferase.	Transketolase.	0.816
APR83066.1	APR83068.1	A7982_08415	A7982_08417	N-Acetylneuraminate cytidylyltransferase.	Transketolase.	0.815
APR83066.1	APR83069.1	A7982_08415	A7982_08418	N-Acetylneuraminate cytidylyltransferase.	Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.988
APR83066.1	APR83070.1	A7982_08415	A7982_08419	N-Acetylneuraminate cytidylyltransferase.	3-oxoacyl-[acyl-carrier protein] reductase.	0.887
APR83066.1	APR83071.1	A7982_08415	A7982_08420	N-Acetylneuraminate cytidylyltransferase.	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase.	0.776
APR83066.1	APR83072.1	A7982_08415	A7982_08421	N-Acetylneuraminate cytidylyltransferase.	N-acetylneuraminate synthase.	0.963
APR83066.1	APR83073.1	A7982_08415	A7982_08422	N-Acetylneuraminate cytidylyltransferase.	Putative sterol desaturase.	0.672
APR83066.1	APR83811.1	A7982_08415	A7982_09160	N-Acetylneuraminate cytidylyltransferase.	dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.494
APR83067.1	APR83065.1	A7982_08416	A7982_08414	Transketolase.	Hypothetical protein.	0.638
APR83067.1	APR83066.1	A7982_08416	A7982_08415	Transketolase.	N-Acetylneuraminate cytidylyltransferase.	0.816

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

33

average node degree:

6.6

avg. local clustering coefficient:

0.861

expected number of edges:

9

PPI enrichment p-value:

1.72e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

3 of 6

2.51

1.97

0.00028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050313

Sulfur dioxygenase activity

3 of 3

2.82

2.49

3.75e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2632

Mixed, incl. Methylglyoxal catabolic process, and Rhodanese Homology Domain

8 of 24

2.34

6.64

7.77e-15

CL:2664

Sulphur transport, and Sulfite exporter TauE/SafE

5 of 8

2.61

4.73

1.48e-09

CL:2636

Rhodanese Homology Domain, and Methylglyoxal catabolic process

3 of 11

2.25

1.88

0.00032

CL:2638

Mixed, incl. Sulfur dioxygenase activity, and tRNA pseudouridine synthesis

2 of 6

2.34

1.05

0.0134

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00620

Pyruvate metabolism

3 of 46

1.63

1.08

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04143

Sulphur transport

3 of 4

2.69

2.32

7.10e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036873

Rhodanese-like domain superfamily

4 of 9

2.46

2.94

3.71e-06

IPR001763

Rhodanese-like domain

4 of 9

2.46

2.94

3.71e-06

IPR044528

Persulfide dioxygenase-like, MBL-fold metallo-hydrolase domain

3 of 3

2.82

2.52

3.25e-05

IPR007272

Sulphur transport domain

3 of 3

2.82

2.52

3.25e-05

IPR001279

Metallo-beta-lactamase

3 of 17

2.06

1.56

0.0011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00450

Rhodanese Homology Domain

4 of 8

2.51

3.58

2.16e-07

SM00849

Metallo-beta-lactamase superfamily

3 of 16

2.09

1.93

0.00020

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Textmining

Cooccurrence

Databases

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About