STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFG37525.1Caspase domain-containing protein; PFAM: Caspase domain. (706 aa)    
Predicted Functional Partners:
AFG37527.1
PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; manually curated; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.955
AFG37526.1
Hypothetical protein.
     
 0.794
AFG37528.1
ADP-ribose pyrophosphatase; PFAM: NUDIX domain.
     
 0.786
AFG38374.1
Outer membrane receptor protein; PFAM: TonB-dependent Receptor Plug Domain.
 
   
 0.677
AFG36328.1
Hypothetical protein.
 
 
   0.668
AFG36748.1
PFAM: Glycosyltransferase family 28 C-terminal domain; TIGRFAM: conserved hypothetical protein.
  
     0.646
AFG37523.1
Putative glutamine amidotransferase; PFAM: Peptidase C26.
       0.642
AFG37524.1
Putative ATP-grasp enzyme; PFAM: ATP-grasp domain; manually curated.
       0.642
AFG38102.1
Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA gyrase B; DNA gyrase B subunit, carboxyl terminus.
   
 
 0.628
gyrB
Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA stran [...]
   
 
 0.628
Your Current Organism:
Spirochaeta africana
NCBI taxonomy Id: 889378
Other names: S. africana DSM 8902, Spirochaeta africana DSM 8902, Spirochaeta africana Z-7692, Spirochaeta africana str. DSM 8902, Spirochaeta africana strain DSM 8902
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