STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFG38441.1Heat shock protein; PFAM: META domain. (262 aa)    
Predicted Functional Partners:
AFG37273.1
UDP-forming alpha,alpha-trehalose-phosphate synthase; PFAM: Trehalose-phosphatase; Glycosyltransferase family 20; TIGRFAM: trehalose-phosphatase; alpha,alpha-trehalose-phosphate synthase [UDP-forming]; HAD-superfamily hydrolase, subfamily IIB.
  
    0.849
AFG36246.1
PFAM: NADPH-dependent FMN reductase; TIGRFAM: NAD(P)H:quinone oxidoreductase, type IV; Belongs to the WrbA family.
   
  
 0.803
AFG37410.1
TIGRFAM: RHS repeat-associated core domain; YD repeat (two copies).
  
  
 0.618
AFG38759.1
PFAM: Hsp70 protein.
  
  
 0.611
AFG36597.1
Hypothetical protein.
   
    0.585
AFG37561.1
Zn-ribbon protein, possibly nucleic acid-binding protein; PFAM: Putative zinc ribbon domain.
    
   0.571
AFG38141.1
Flagellar basal body-associated protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.
    
   0.571
AFG38442.1
Putative oxidoreductase, aryl-alcohol dehydrogenase like protein; PFAM: Aldo/keto reductase family.
  
    0.535
AFG38103.1
PFAM: DNA gyrase/topoisomerase IV, subunit A.
  
  
 0.487
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.487
Your Current Organism:
Spirochaeta africana
NCBI taxonomy Id: 889378
Other names: S. africana DSM 8902, Spirochaeta africana DSM 8902, Spirochaeta africana Z-7692, Spirochaeta africana str. DSM 8902, Spirochaeta africana strain DSM 8902
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