node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFG36593.1 | AFG38092.1 | Spiaf_0490 | Spiaf_2044 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | OAH/OAS sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.950 |
AFG36593.1 | AFG38093.1 | Spiaf_0490 | Spiaf_2045 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.886 |
AFG36593.1 | AFG38323.1 | Spiaf_0490 | Spiaf_2290 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.977 |
AFG36593.1 | AFG38591.1 | Spiaf_0490 | Spiaf_2561 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.455 |
AFG36593.1 | AFG38592.1 | Spiaf_0490 | Spiaf_2562 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; PFAM: Aminotransferase class I and II. | 0.927 |
AFG36593.1 | ahcY | Spiaf_0490 | Spiaf_0010 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.949 |
AFG36593.1 | metZ | Spiaf_0490 | Spiaf_2450 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.982 |
AFG37375.1 | AFG38063.1 | Spiaf_1300 | Spiaf_2013 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | 0.918 |
AFG37375.1 | AFG38093.1 | Spiaf_1300 | Spiaf_2045 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.830 |
AFG37375.1 | AFG38592.1 | Spiaf_1300 | Spiaf_2562 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; PFAM: Aminotransferase class I and II. | 0.900 |
AFG37375.1 | AFG38641.1 | Spiaf_1300 | Spiaf_2615 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | 0.924 |
AFG37375.1 | metZ | Spiaf_1300 | Spiaf_2450 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.839 |
AFG38063.1 | AFG37375.1 | Spiaf_2013 | Spiaf_1300 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | 0.918 |
AFG38063.1 | AFG38093.1 | Spiaf_2013 | Spiaf_2045 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.830 |
AFG38063.1 | AFG38592.1 | Spiaf_2013 | Spiaf_2562 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; PFAM: Aminotransferase class I and II. | 0.900 |
AFG38063.1 | AFG38641.1 | Spiaf_2013 | Spiaf_2615 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | 0.925 |
AFG38063.1 | metZ | Spiaf_2013 | Spiaf_2450 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.837 |
AFG38092.1 | AFG36593.1 | Spiaf_2044 | Spiaf_0490 | OAH/OAS sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.950 |
AFG38092.1 | AFG38093.1 | Spiaf_2044 | Spiaf_2045 | OAH/OAS sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.929 |
AFG38092.1 | AFG38323.1 | Spiaf_2044 | Spiaf_2290 | OAH/OAS sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.939 |