SFV41807.1 protein (Lactobacillus acidipiscis)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

SFV41807.1

Universal stress protein family. (148 aa)

Predicted Functional Partners:

SFV41806.1

0.797

SFV41492.1

0.679

SFV41805.1

0.553

SFV40636.1

0.533

SFV40330.1

0.507

SFV41104.1

0.498

SFV40637.1

0.441

SFV40147.1

0.426

SFV41804.1

0.408

SFV40629.1

0.407

Your Current Organism:

Lactobacillus acidipiscis

NCBI taxonomy Id: 89059
Other names: CCUG 42961 [[Lactobacillus cypricasei]], CCUG 46556, CIP 106393 [[Lactobacillus cypricasei]], CIP 106750, DSM 15353 [[Lactobacillus cypricasei]], DSM 15836, JCM 10692, KCTC 13900 [[Lactobacillus cypricasei]], L. acidipiscis, Lactobacillus acidipiscis Tanasupawat et al. 2000, Lactobacillus cypricasei, Lactobacillus cypricasei Lawson et al. 2001, Lactobacillus sp. FS60-1, Lactobacillus sp. FS60-1T, Lactobacillus sp. LMG 17676, Lactobacillus sp. LMK3, NBRC 102163, NRIC 0300, PCU 207, PCU:207, strain FS60-1, strain LMK3 [[Lactobacillus cypricasei]]

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFV40147.1	SFV41104.1	LAC1533_0727	LAC1533_1683	Hypothetical protein.	Putative pheromone cAM373 precursor lipoprotein CamS.	0.595
SFV40147.1	SFV41807.1	LAC1533_0727	LAC1533_2381	Hypothetical protein.	Universal stress protein family.	0.426
SFV40330.1	SFV40629.1	LAC1533_0910	LAC1533_1209	DNA methyltransferase.	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	0.761
SFV40330.1	SFV40637.1	LAC1533_0910	LAC1533_1217	DNA methyltransferase.	YfaA.	0.554
SFV40330.1	SFV41104.1	LAC1533_0910	LAC1533_1683	DNA methyltransferase.	Putative pheromone cAM373 precursor lipoprotein CamS.	0.502
SFV40330.1	SFV41492.1	LAC1533_0910	LAC1533_2069	DNA methyltransferase.	Universal stress protein family.	0.625
SFV40330.1	SFV41807.1	LAC1533_0910	LAC1533_2381	DNA methyltransferase.	Universal stress protein family.	0.507
SFV40629.1	SFV40330.1	LAC1533_1209	LAC1533_0910	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	DNA methyltransferase.	0.761
SFV40629.1	SFV40636.1	LAC1533_1209	LAC1533_1216	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	FIG006988: Lipase/Acylhydrolase with GDSL-like motif.	0.585
SFV40629.1	SFV40637.1	LAC1533_1209	LAC1533_1217	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	YfaA.	0.723
SFV40629.1	SFV41104.1	LAC1533_1209	LAC1533_1683	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	Putative pheromone cAM373 precursor lipoprotein CamS.	0.551
SFV40629.1	SFV41492.1	LAC1533_1209	LAC1533_2069	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	Universal stress protein family.	0.402
SFV40629.1	SFV41807.1	LAC1533_1209	LAC1533_2381	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	Universal stress protein family.	0.407
SFV40636.1	SFV40629.1	LAC1533_1216	LAC1533_1209	FIG006988: Lipase/Acylhydrolase with GDSL-like motif.	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	0.585
SFV40636.1	SFV40637.1	LAC1533_1216	LAC1533_1217	FIG006988: Lipase/Acylhydrolase with GDSL-like motif.	YfaA.	0.976
SFV40636.1	SFV41104.1	LAC1533_1216	LAC1533_1683	FIG006988: Lipase/Acylhydrolase with GDSL-like motif.	Putative pheromone cAM373 precursor lipoprotein CamS.	0.451
SFV40636.1	SFV41807.1	LAC1533_1216	LAC1533_2381	FIG006988: Lipase/Acylhydrolase with GDSL-like motif.	Universal stress protein family.	0.533
SFV40637.1	SFV40330.1	LAC1533_1217	LAC1533_0910	YfaA.	DNA methyltransferase.	0.554
SFV40637.1	SFV40629.1	LAC1533_1217	LAC1533_1209	YfaA.	TPR-repeat-containing protein, putative component of Menaquinone-cytochrome C reductase.	0.723
SFV40637.1	SFV40636.1	LAC1533_1217	LAC1533_1216	YfaA.	FIG006988: Lipase/Acylhydrolase with GDSL-like motif.	0.976

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.876

expected number of edges:

10

PPI enrichment p-value:

0.00102

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006284

Base-excision repair

7 of 20

2.44

5.78

1.47e-12

GO:0006285

Base-excision repair, AP site formation

5 of 8

2.69

4.53

2.62e-09

GO:0006281

DNA repair

8 of 234

1.43

2.13

6.25e-08

GO:0097510

Base-excision repair, AP site formation via deaminated base removal

2 of 2

2.89

1.41

0.0028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019104

DNA N-glycosylase activity

5 of 12

2.51

4.26

5.27e-09

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

4 of 5

2.79

3.91

5.28e-08

GO:0140097

Catalytic activity, acting on DNA

9 of 153

1.66

3.39

1.87e-11

GO:0000702

Oxidized base lesion DNA N-glycosylase activity

3 of 8

2.47

2.28

5.29e-05

GO:0140078

Class I DNA-(apurinic or apyrimidinic site) endonuclease activity

2 of 3

2.72

1.47

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7191

Base-excision repair

5 of 10

2.59

4.32

5.37e-09

CL:7196

DNA-(apurinic or apyrimidinic site) endonuclease activity, and DNA dealkylation

4 of 5

2.79

3.7

1.38e-07

CL:6867

DNA metabolic process

7 of 175

1.49

2.17

2.66e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03410

Base excision repair

7 of 40

2.13

4.97

4.54e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73929

Base-Excision Repair, AP Site Formation

4 of 14

2.35

2.89

2.47e-06

MAP-73884

Base Excision Repair

5 of 46

1.93

2.57

2.47e-06

MAP-73928

Depyrimidination

3 of 7

2.52

2.34

4.24e-05

MAP-110329

Cleavage of the damaged pyrimidine

3 of 7

2.52

2.34

4.24e-05

MAP-73894

DNA Repair

6 of 223

1.32

1.45

4.22e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0227

DNA damage

3 of 27

1.94

1.44

0.0014

KW-0234

DNA repair

2 of 21

1.87

0.78

0.0330

KW-0378

Hydrolase

4 of 271

1.06

0.58

0.0330

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000445

Helix-hairpin-helix motif

2 of 2

2.89

0.91

0.0224

IPR023170

Helix-hairpin-helix, base-excision DNA repair, C-terminal

2 of 4

2.59

0.86

0.0280

IPR003265

HhH-GPD domain

2 of 4

2.59

0.86

0.0280

IPR011257

DNA glycosylase

2 of 7

2.35

0.81

0.0335

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00478

Endonuclease III

2 of 3

2.72

1.29

0.0045

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