node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDG18019.1 | SDH75715.1 | SAMN05216605_101350 | SAMN05216605_10853 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Hypoxanthine phosphoribosyltransferase. | 0.868 |
SDG18019.1 | SDH97976.1 | SAMN05216605_101350 | SAMN05216605_109253 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Xanthine dehydrogenase, molybdenum binding subunit apoprotein. | 0.737 |
SDG18019.1 | SDI49925.1 | SAMN05216605_101350 | SAMN05216605_11415 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | 0.838 |
SDG18019.1 | amn | SAMN05216605_101350 | SAMN05216605_116107 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. | 0.780 |
SDG18019.1 | apt | SAMN05216605_101350 | SAMN05216605_11152 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.955 |
SDG18019.1 | guaB | SAMN05216605_101350 | SAMN05216605_105318 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.811 |
SDG18019.1 | surE | SAMN05216605_101350 | SAMN05216605_105196 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.706 |
SDG18019.1 | xpt | SAMN05216605_101350 | SAMN05216605_11091 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.809 |
SDH75715.1 | SDG18019.1 | SAMN05216605_10853 | SAMN05216605_101350 | Hypoxanthine phosphoribosyltransferase. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.868 |
SDH75715.1 | SDH97976.1 | SAMN05216605_10853 | SAMN05216605_109253 | Hypoxanthine phosphoribosyltransferase. | Xanthine dehydrogenase, molybdenum binding subunit apoprotein. | 0.665 |
SDH75715.1 | SDI49925.1 | SAMN05216605_10853 | SAMN05216605_11415 | Hypoxanthine phosphoribosyltransferase. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | 0.806 |
SDH75715.1 | amn | SAMN05216605_10853 | SAMN05216605_116107 | Hypoxanthine phosphoribosyltransferase. | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. | 0.703 |
SDH75715.1 | apt | SAMN05216605_10853 | SAMN05216605_11152 | Hypoxanthine phosphoribosyltransferase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.765 |
SDH75715.1 | guaB | SAMN05216605_10853 | SAMN05216605_105318 | Hypoxanthine phosphoribosyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.775 |
SDH75715.1 | purA | SAMN05216605_10853 | SAMN05216605_103227 | Hypoxanthine phosphoribosyltransferase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.816 |
SDH75715.1 | purH | SAMN05216605_10853 | SAMN05216605_103312 | Hypoxanthine phosphoribosyltransferase. | IMP cyclohydrolase. | 0.795 |
SDH75715.1 | surE | SAMN05216605_10853 | SAMN05216605_105196 | Hypoxanthine phosphoribosyltransferase. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.625 |
SDH75715.1 | xpt | SAMN05216605_10853 | SAMN05216605_11091 | Hypoxanthine phosphoribosyltransferase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.752 |
SDH97976.1 | SDG18019.1 | SAMN05216605_109253 | SAMN05216605_101350 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.737 |
SDH97976.1 | SDH75715.1 | SAMN05216605_109253 | SAMN05216605_10853 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein. | Hypoxanthine phosphoribosyltransferase. | 0.665 |