| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00145 | mraZ | ISM_00145 | ISM_00160 | COG0768 Cell division protein FtsI/penicillin-binding protein 2. | MraZ, putative; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. | 0.893 |
| ISM_00145 | murE | ISM_00145 | ISM_00140 | COG0768 Cell division protein FtsI/penicillin-binding protein 2. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.993 |
| ISM_00145 | rsmH | ISM_00145 | ISM_00155 | COG0768 Cell division protein FtsI/penicillin-binding protein 2. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.937 |
| ISM_10720 | rsmH | ISM_10720 | ISM_00155 | Hypothetical protein; COG0491 Zn-dependent hydrolases, including glyoxylases. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.957 |
| ISM_10720 | truA | ISM_10720 | ISM_08525 | Hypothetical protein; COG0491 Zn-dependent hydrolases, including glyoxylases. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.967 |
| mraZ | ISM_00145 | ISM_00160 | ISM_00145 | MraZ, putative; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. | COG0768 Cell division protein FtsI/penicillin-binding protein 2. | 0.893 |
| mraZ | murE | ISM_00160 | ISM_00140 | MraZ, putative; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.830 |
| mraZ | rsmH | ISM_00160 | ISM_00155 | MraZ, putative; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.986 |
| murE | ISM_00145 | ISM_00140 | ISM_00145 | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | COG0768 Cell division protein FtsI/penicillin-binding protein 2. | 0.993 |
| murE | mraZ | ISM_00140 | ISM_00160 | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | MraZ, putative; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. | 0.830 |
| murE | rsmH | ISM_00140 | ISM_00155 | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.927 |
| rpsB | rpsG | ISM_15660 | ISM_01865 | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.999 |
| rpsB | rpsI | ISM_15660 | ISM_16290 | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | COG0103 Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. | 0.999 |
| rpsB | rpsO | ISM_15660 | ISM_06390 | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.999 |
| rpsB | rpsP | ISM_15660 | ISM_08830 | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | COG0228 Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. | 0.999 |
| rpsB | rsmH | ISM_15660 | ISM_00155 | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.920 |
| rpsG | rpsB | ISM_01865 | ISM_15660 | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.999 |
| rpsG | rpsI | ISM_01865 | ISM_16290 | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | COG0103 Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. | 0.999 |
| rpsG | rpsO | ISM_01865 | ISM_06390 | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.999 |
| rpsG | rpsP | ISM_01865 | ISM_08830 | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | COG0228 Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. | 0.999 |