Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_00170COG0404 Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. (365 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 0.980
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.939
dddP
Metallopeptidase, family M24; Able to cleave dimethlysulfonioproprionate (DMSP), releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere. The real activity of the protein is however subject to debate and it is unclear whether it constitutes a real dimethlysulfonioproprionate lyase in vivo: the low activity with DMSP as substrate suggests that DMSP is not its native substrate.
  
 
 0.870
ISM_02075
AMP-binding protein; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
     
  0.850
ISM_00180
Hypothetical protein.
 
     0.839
ISM_00175
DinB family protein; COG2318 Uncharacterized protein conserved in bacteria.
       0.786
ISM_00185
Membrane protein, putative; COG5486 Predicted metal-binding integral membrane protein.
 
     0.779
ISM_07675
Hypothetical protein; COG0509 Glycine cleavage system H protein (lipoate-binding).
  
 0.775
ISM_09351
COG4583 Sarcosine oxidase gamma subunit.
 
  0.686
ISM_08410
COG0112 Glycine/serine hydroxymethyltransferase.
  
 0.677
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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