| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00215 | ISM_01565 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | 0.989 |
| ISM_00215 | ISM_04775 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.983 |
| ISM_00215 | ISM_05265 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Diguanylate cyclase, putative; COG2200 FOG: EAL domain. | 0.997 |
| ISM_00215 | ISM_05545 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.985 |
| ISM_00215 | ISM_05685 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. | 0.998 |
| ISM_00215 | ISM_05910 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.997 |
| ISM_00215 | ISM_06625 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.993 |
| ISM_00215 | ISM_06925 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.999 |
| ISM_00215 | ISM_07425 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.980 |
| ISM_00215 | ISM_09486 | Hypothetical protein; COG2199 FOG: GGDEF domain. | COG2200 FOG: EAL domain. | 0.996 |
| ISM_01565 | ISM_00215 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.989 |
| ISM_01565 | ISM_04775 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.989 |
| ISM_01565 | ISM_05265 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Diguanylate cyclase, putative; COG2200 FOG: EAL domain. | 0.854 |
| ISM_01565 | ISM_05545 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.994 |
| ISM_01565 | ISM_05685 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. | 0.929 |
| ISM_01565 | ISM_05910 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.794 |
| ISM_01565 | ISM_06625 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.941 |
| ISM_01565 | ISM_06925 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.970 |
| ISM_01565 | ISM_07425 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.941 |
| ISM_01565 | ISM_09486 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | COG2200 FOG: EAL domain. | 0.415 |