| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00220 | ISM_00225 | ISM_00220 | ISM_00225 | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | Putative ABC transporter ATP-binding protein; COG4172 ABC-type uncharacterized transport system, duplicated ATPase component. | 0.562 |
| ISM_00220 | ISM_06100 | ISM_00220 | ISM_06100 | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.655 |
| ISM_00220 | ISM_10156 | ISM_00220 | ISM_10156 | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | Gamma-glutamyltranspeptidase, putative; COG0405 Gamma-glutamyltransferase. | 0.409 |
| ISM_00220 | dapD | ISM_00220 | ISM_02195 | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | COG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. | 0.486 |
| ISM_00220 | dapF | ISM_00220 | ISM_02695 | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.420 |
| ISM_00225 | ISM_00220 | ISM_00225 | ISM_00220 | Putative ABC transporter ATP-binding protein; COG4172 ABC-type uncharacterized transport system, duplicated ATPase component. | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | 0.562 |
| ISM_06100 | ISM_00220 | ISM_06100 | ISM_00220 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | 0.655 |
| ISM_06100 | ISM_10156 | ISM_06100 | ISM_10156 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Gamma-glutamyltranspeptidase, putative; COG0405 Gamma-glutamyltransferase. | 0.814 |
| ISM_06100 | dapF | ISM_06100 | ISM_02695 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.939 |
| ISM_10156 | ISM_00220 | ISM_10156 | ISM_00220 | Gamma-glutamyltranspeptidase, putative; COG0405 Gamma-glutamyltransferase. | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | 0.409 |
| ISM_10156 | ISM_06100 | ISM_10156 | ISM_06100 | Gamma-glutamyltranspeptidase, putative; COG0405 Gamma-glutamyltransferase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.814 |
| dapD | ISM_00220 | ISM_02195 | ISM_00220 | COG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | 0.486 |
| dapD | dapF | ISM_02195 | ISM_02695 | COG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.528 |
| dapF | ISM_00220 | ISM_02695 | ISM_00220 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | Amidohydrolase family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. | 0.420 |
| dapF | ISM_06100 | ISM_02695 | ISM_06100 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.939 |
| dapF | dapD | ISM_02695 | ISM_02195 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | COG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. | 0.528 |