| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00405 | ISM_01455 | ISM_00405 | ISM_01455 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | COG2025 Electron transfer flavoprotein, alpha subunit. | 0.743 |
| ISM_00405 | ISM_02615 | ISM_00405 | ISM_02615 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.855 |
| ISM_00405 | ISM_05245 | ISM_00405 | ISM_05245 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.873 |
| ISM_00405 | ISM_08575 | ISM_00405 | ISM_08575 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | L-lactate dehydrogenase, putative; COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases. | 0.917 |
| ISM_00405 | ISM_09586 | ISM_00405 | ISM_09586 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | Malate dehydrogenase; COG0281 Malic enzyme. | 0.873 |
| ISM_00405 | ISM_09846 | ISM_00405 | ISM_09846 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase. | 0.854 |
| ISM_00405 | ISM_16905 | ISM_00405 | ISM_16905 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases. | 0.917 |
| ISM_00405 | ISM_16910 | ISM_00405 | ISM_16910 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.871 |
| ISM_00405 | gloB | ISM_00405 | ISM_11705 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | Putative hydroxyacylglutathione hydrolase (glyoxalase II) (GLX II)protein; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | 0.850 |
| ISM_00405 | pdhA | ISM_00405 | ISM_05250 | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | Pyruvate dehydrogenase complex, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.863 |
| ISM_01455 | ISM_00405 | ISM_01455 | ISM_00405 | COG2025 Electron transfer flavoprotein, alpha subunit. | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | 0.743 |
| ISM_01455 | ISM_02615 | ISM_01455 | ISM_02615 | COG2025 Electron transfer flavoprotein, alpha subunit. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.589 |
| ISM_01455 | ISM_05245 | ISM_01455 | ISM_05245 | COG2025 Electron transfer flavoprotein, alpha subunit. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.946 |
| ISM_01455 | ISM_09586 | ISM_01455 | ISM_09586 | COG2025 Electron transfer flavoprotein, alpha subunit. | Malate dehydrogenase; COG0281 Malic enzyme. | 0.519 |
| ISM_01455 | ISM_09846 | ISM_01455 | ISM_09846 | COG2025 Electron transfer flavoprotein, alpha subunit. | Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase. | 0.414 |
| ISM_01455 | ISM_16910 | ISM_01455 | ISM_16910 | COG2025 Electron transfer flavoprotein, alpha subunit. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.428 |
| ISM_01455 | pdhA | ISM_01455 | ISM_05250 | COG2025 Electron transfer flavoprotein, alpha subunit. | Pyruvate dehydrogenase complex, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.406 |
| ISM_02615 | ISM_00405 | ISM_02615 | ISM_00405 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Putative D-lactate dehydrogenase (cytochrome), FAD/FMN-containingoxidoreductase; COG0277 FAD/FMN-containing dehydrogenases. | 0.855 |
| ISM_02615 | ISM_01455 | ISM_02615 | ISM_01455 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG2025 Electron transfer flavoprotein, alpha subunit. | 0.589 |
| ISM_02615 | ISM_05245 | ISM_02615 | ISM_05245 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.918 |