| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00490 | ISM_00500 | ISM_00490 | ISM_00500 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | COG4591 ABC-type transport system, involved in lipoprotein release, permease component. | 0.725 |
| ISM_00490 | ISM_05425 | ISM_00490 | ISM_05425 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | Peptidase, M19 family protein; COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog. | 0.735 |
| ISM_00490 | ISM_06675 | ISM_00490 | ISM_06675 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | Phosphate acetyltransferase; COG0281 Malic enzyme. | 0.785 |
| ISM_00490 | ISM_08755 | ISM_00490 | ISM_08755 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | COG1448 Aspartate/tyrosine/aromatic aminotransferase. | 0.922 |
| ISM_00490 | ISM_09586 | ISM_00490 | ISM_09586 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | Malate dehydrogenase; COG0281 Malic enzyme. | 0.785 |
| ISM_00490 | ISM_10526 | ISM_00490 | ISM_10526 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.814 |
| ISM_00490 | ISM_13065 | ISM_00490 | ISM_13065 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | Renal dipeptidase family protein; COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog. | 0.813 |
| ISM_00490 | ISM_13135 | ISM_00490 | ISM_13135 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.911 |
| ISM_00490 | lolD | ISM_00490 | ISM_00495 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | Lipoprotein releasing system ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | 0.677 |
| ISM_00490 | mdh | ISM_00490 | ISM_05055 | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.929 |
| ISM_00500 | ISM_00490 | ISM_00500 | ISM_00490 | COG4591 ABC-type transport system, involved in lipoprotein release, permease component. | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.725 |
| ISM_00500 | lolD | ISM_00500 | ISM_00495 | COG4591 ABC-type transport system, involved in lipoprotein release, permease component. | Lipoprotein releasing system ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | 0.999 |
| ISM_05425 | ISM_00490 | ISM_05425 | ISM_00490 | Peptidase, M19 family protein; COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog. | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.735 |
| ISM_06675 | ISM_00490 | ISM_06675 | ISM_00490 | Phosphate acetyltransferase; COG0281 Malic enzyme. | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.785 |
| ISM_06675 | ISM_09586 | ISM_06675 | ISM_09586 | Phosphate acetyltransferase; COG0281 Malic enzyme. | Malate dehydrogenase; COG0281 Malic enzyme. | 0.798 |
| ISM_06675 | ISM_10526 | ISM_06675 | ISM_10526 | Phosphate acetyltransferase; COG0281 Malic enzyme. | COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.606 |
| ISM_06675 | ISM_13135 | ISM_06675 | ISM_13135 | Phosphate acetyltransferase; COG0281 Malic enzyme. | COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.720 |
| ISM_06675 | mdh | ISM_06675 | ISM_05055 | Phosphate acetyltransferase; COG0281 Malic enzyme. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.914 |
| ISM_08755 | ISM_00490 | ISM_08755 | ISM_00490 | COG1448 Aspartate/tyrosine/aromatic aminotransferase. | COG2055 Malate/L-lactate dehydrogenases; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.922 |
| ISM_08755 | ISM_10526 | ISM_08755 | ISM_10526 | COG1448 Aspartate/tyrosine/aromatic aminotransferase. | COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.754 |