STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_00530Phosphatase, Ppx/GppA family protein; COG0248 Exopolyphosphatase. (508 aa)    
Predicted Functional Partners:
ppk
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.
 
  
 0.961
ISM_13785
guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
 
 
 0.943
ISM_15130
Phosphatase, Ppx/GppA family protein; COG0248 Exopolyphosphatase.
  
  
0.934
ISM_00515
Membrane protein; COG0628 Predicted permease.
       0.696
ISM_00520
Hypothetical protein; COG0593 ATPase involved in DNA replication initiation.
       0.696
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro); Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
       0.519
ISM_06820
ATP-dependent DNA helicase, UvrD/Rep family protein; COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); Belongs to the helicase family. UvrD subfamily.
  
     0.495
ISM_16280
Polyphosphate kinase 2, putative.
 
  
 0.471
ISM_16370
Hypothetical protein; COG1399 Predicted metal-binding, possibly nucleic acid-binding protein.
 
 
   0.468
ISM_16365
Lipoprotein, SmpA/OmlA family protein; COG2913 Small protein A (tmRNA-binding).
  
     0.464
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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