STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ISM_01110ABC transporter, ATP binding/permease protein; COG1132 ABC-type multidrug transport system, ATPase and permease components. (598 aa)    
Predicted Functional Partners:
ISM_00695
Probable ATP-binding/permease fusion ABC transporter; COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain.
   
 0.817
ISM_16740
Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins.
  
 0.762
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.724
ISM_17790
COG0464 ATPases of the AAA+ class.
 
 
 0.717
ISM_09371
ABC transporter, ATP-binding/permease protein; COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components.
  
 
0.714
ISM_11670
ATP-dependent helicase HrpB; COG1643 HrpA-like helicases.
    
  0.693
ISM_02950
ABC transporter, ATP-binding protein; COG1131 ABC-type multidrug transport system, ATPase component.
  
 0.681
ISM_09085
ABC transporter, ATP-binding protein; COG1131 ABC-type multidrug transport system, ATPase component.
  
 0.681
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 
 0.680
ISM_11250
Hypothetical protein; COG0464 ATPases of the AAA+ class.
   
 0.665
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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