| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00545 | clpX | ISM_00545 | ISM_01305 | Putative heat shock protein DnaJ; COG1076 DnaJ-domain-containing proteins 1. | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.697 |
| ISM_01300 | clpP | ISM_01300 | ISM_01310 | COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit. | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.428 |
| ISM_01300 | clpX | ISM_01300 | ISM_01305 | COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit. | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.661 |
| ISM_15515 | ISM_15520 | ISM_15515 | ISM_15520 | COG0466 ATP-dependent Lon protease, bacterial type. | COG0466 ATP-dependent Lon protease, bacterial type. | 0.994 |
| ISM_15515 | clpP | ISM_15515 | ISM_01310 | COG0466 ATP-dependent Lon protease, bacterial type. | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.637 |
| ISM_15515 | clpX | ISM_15515 | ISM_01305 | COG0466 ATP-dependent Lon protease, bacterial type. | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.626 |
| ISM_15515 | ftsH | ISM_15515 | ISM_03280 | COG0466 ATP-dependent Lon protease, bacterial type. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.742 |
| ISM_15520 | ISM_15515 | ISM_15520 | ISM_15515 | COG0466 ATP-dependent Lon protease, bacterial type. | COG0466 ATP-dependent Lon protease, bacterial type. | 0.994 |
| ISM_15520 | clpP | ISM_15520 | ISM_01310 | COG0466 ATP-dependent Lon protease, bacterial type. | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.637 |
| ISM_15520 | clpX | ISM_15520 | ISM_01305 | COG0466 ATP-dependent Lon protease, bacterial type. | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.626 |
| ISM_15520 | ftsH | ISM_15520 | ISM_03280 | COG0466 ATP-dependent Lon protease, bacterial type. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.758 |
| atpD | clpX | ISM_11745 | ISM_01305 | ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.770 |
| atpD | ftsH | ISM_11745 | ISM_03280 | ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.567 |
| atpD | ftsZ | ISM_11745 | ISM_00580 | ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.444 |
| atpD | guaB | ISM_11745 | ISM_14860 | ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.485 |
| clpP | ISM_01300 | ISM_01310 | ISM_01300 | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit. | 0.428 |
| clpP | ISM_15515 | ISM_01310 | ISM_15515 | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | COG0466 ATP-dependent Lon protease, bacterial type. | 0.637 |
| clpP | ISM_15520 | ISM_01310 | ISM_15520 | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | COG0466 ATP-dependent Lon protease, bacterial type. | 0.637 |
| clpP | clpX | ISM_01310 | ISM_01305 | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.999 |
| clpP | ftsH | ISM_01310 | ISM_03280 | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.507 |
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