| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02445 | rppH | ISM_02445 | ISM_02440 | Hypothetical protein. | Hydrolase, NUDIX family protein of the NudH subfamily; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.845 |
| ISM_03735 | nnrD | ISM_03735 | ISM_05415 | Putative ATP-dependent RNA helicase protein; COG0513 Superfamily II DNA and RNA helicases. | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.808 |
| ISM_03735 | rnr | ISM_03735 | ISM_11690 | Putative ATP-dependent RNA helicase protein; COG0513 Superfamily II DNA and RNA helicases. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.769 |
| ISM_03735 | rppH | ISM_03735 | ISM_02440 | Putative ATP-dependent RNA helicase protein; COG0513 Superfamily II DNA and RNA helicases. | Hydrolase, NUDIX family protein of the NudH subfamily; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.670 |
| ISM_11350 | ribB | ISM_11350 | ISM_00120 | COG1536 Flagellar motor switch protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.850 |
| ISM_11350 | rppH | ISM_11350 | ISM_02440 | COG1536 Flagellar motor switch protein. | Hydrolase, NUDIX family protein of the NudH subfamily; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.648 |
| ISM_14115 | ISM_14135 | ISM_14115 | ISM_14135 | ATP-dependent RNA helicase, DEAD/DEAH box family protein; COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.422 |
| ISM_14115 | nnrD | ISM_14115 | ISM_05415 | ATP-dependent RNA helicase, DEAD/DEAH box family protein; COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.808 |
| ISM_14115 | rnr | ISM_14115 | ISM_11690 | ATP-dependent RNA helicase, DEAD/DEAH box family protein; COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.679 |
| ISM_14115 | rppH | ISM_14115 | ISM_02440 | ATP-dependent RNA helicase, DEAD/DEAH box family protein; COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | Hydrolase, NUDIX family protein of the NudH subfamily; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.670 |
| ISM_14135 | ISM_14115 | ISM_14135 | ISM_14115 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | ATP-dependent RNA helicase, DEAD/DEAH box family protein; COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | 0.422 |
| ISM_14135 | nnrD | ISM_14135 | ISM_05415 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.402 |
| ISM_14135 | ribB | ISM_14135 | ISM_00120 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.414 |
| ISM_14135 | rppH | ISM_14135 | ISM_02440 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | Hydrolase, NUDIX family protein of the NudH subfamily; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.581 |
| ISM_17200 | nnrD | ISM_17200 | ISM_05415 | COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.808 |
| ISM_17200 | rnr | ISM_17200 | ISM_11690 | COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.770 |
| ISM_17200 | rppH | ISM_17200 | ISM_02440 | COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. | Hydrolase, NUDIX family protein of the NudH subfamily; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.670 |
| dapF | ribB | ISM_02695 | ISM_00120 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.548 |
| dapF | rppH | ISM_02695 | ISM_02440 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | Hydrolase, NUDIX family protein of the NudH subfamily; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.844 |
| nnrD | ISM_03735 | ISM_05415 | ISM_03735 | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | Putative ATP-dependent RNA helicase protein; COG0513 Superfamily II DNA and RNA helicases. | 0.808 |
