| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_03055 | ISM_03060 | ISM_03055 | ISM_03060 | COG0642 Signal transduction histidine kinase. | Mercuric reductase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.818 |
| ISM_03055 | ISM_03065 | ISM_03055 | ISM_03065 | COG0642 Signal transduction histidine kinase. | Membrane protein, putative. | 0.759 |
| ISM_03055 | ISM_03075 | ISM_03055 | ISM_03075 | COG0642 Signal transduction histidine kinase. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.552 |
| ISM_03055 | ISM_05085 | ISM_03055 | ISM_05085 | COG0642 Signal transduction histidine kinase. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.530 |
| ISM_03055 | ISM_10850 | ISM_03055 | ISM_10850 | COG0642 Signal transduction histidine kinase. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.479 |
| ISM_03055 | ISM_12135 | ISM_03055 | ISM_12135 | COG0642 Signal transduction histidine kinase. | Glutathione-disulfide reductase; Maintains high levels of reduced glutathione. | 0.460 |
| ISM_03055 | rpmH | ISM_03055 | ISM_03070 | COG0642 Signal transduction histidine kinase. | COG0230 Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. | 0.555 |
| ISM_03060 | ISM_03055 | ISM_03060 | ISM_03055 | Mercuric reductase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG0642 Signal transduction histidine kinase. | 0.818 |
| ISM_03060 | ISM_03065 | ISM_03060 | ISM_03065 | Mercuric reductase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Membrane protein, putative. | 0.994 |
| ISM_03060 | ISM_05085 | ISM_03060 | ISM_05085 | Mercuric reductase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.613 |
| ISM_03060 | ISM_05560 | ISM_03060 | ISM_05560 | Mercuric reductase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Glycosyl transferase, group 2 family protein; COG0463 Glycosyltransferases involved in cell wall biogenesis. | 0.412 |
| ISM_03060 | ISM_10850 | ISM_03060 | ISM_10850 | Mercuric reductase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.816 |
| ISM_03065 | ISM_03055 | ISM_03065 | ISM_03055 | Membrane protein, putative. | COG0642 Signal transduction histidine kinase. | 0.759 |
| ISM_03065 | ISM_03060 | ISM_03065 | ISM_03060 | Membrane protein, putative. | Mercuric reductase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.994 |
| ISM_03065 | ISM_03075 | ISM_03065 | ISM_03075 | Membrane protein, putative. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.501 |
| ISM_03065 | ISM_03495 | ISM_03065 | ISM_03495 | Membrane protein, putative. | COG1183 Phosphatidylserine synthase. | 0.521 |
| ISM_03065 | ISM_05085 | ISM_03065 | ISM_05085 | Membrane protein, putative. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.663 |
| ISM_03065 | ISM_05560 | ISM_03065 | ISM_05560 | Membrane protein, putative. | Glycosyl transferase, group 2 family protein; COG0463 Glycosyltransferases involved in cell wall biogenesis. | 0.555 |
| ISM_03065 | ISM_10850 | ISM_03065 | ISM_10850 | Membrane protein, putative. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.614 |
| ISM_03065 | ISM_12120 | ISM_03065 | ISM_12120 | Membrane protein, putative. | COG2453 Predicted protein-tyrosine phosphatase. | 0.491 |