| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_03090 | ISM_03100 | ISM_03090 | ISM_03100 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | SURF1 family protein. | 0.923 |
| ISM_03090 | ISM_03105 | ISM_03090 | ISM_03105 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3. | 0.913 |
| ISM_03090 | ISM_03115 | ISM_03090 | ISM_03115 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | Protoheme IX farnesyltransferase. | 0.587 |
| ISM_03090 | ISM_03125 | ISM_03090 | ISM_03125 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | Cytochrome c oxidase, subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | 0.861 |
| ISM_03090 | ISM_04605 | ISM_03090 | ISM_04605 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2. | 0.737 |
| ISM_03090 | ISM_04945 | ISM_03090 | ISM_04945 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; Belongs to the heme-copper respiratory oxidase family. | 0.735 |
| ISM_03090 | ctaA | ISM_03090 | ISM_16075 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | 0.607 |
| ISM_03090 | ctaB | ISM_03090 | ISM_03120 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.596 |
| ISM_03090 | ctaG | ISM_03090 | ISM_03110 | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | Cytochrome C oxidase assembly protein; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I; Belongs to the COX11/CtaG family. | 0.808 |
| ISM_03100 | ISM_03090 | ISM_03100 | ISM_03090 | SURF1 family protein. | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | 0.923 |
| ISM_03100 | ISM_03105 | ISM_03100 | ISM_03105 | SURF1 family protein. | COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3. | 0.876 |
| ISM_03100 | ISM_03115 | ISM_03100 | ISM_03115 | SURF1 family protein. | Protoheme IX farnesyltransferase. | 0.739 |
| ISM_03100 | ISM_03125 | ISM_03100 | ISM_03125 | SURF1 family protein. | Cytochrome c oxidase, subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | 0.915 |
| ISM_03100 | ISM_04605 | ISM_03100 | ISM_04605 | SURF1 family protein. | COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2. | 0.805 |
| ISM_03100 | ISM_04945 | ISM_03100 | ISM_04945 | SURF1 family protein. | COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; Belongs to the heme-copper respiratory oxidase family. | 0.832 |
| ISM_03100 | ISM_06855 | ISM_03100 | ISM_06855 | SURF1 family protein. | COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems. | 0.601 |
| ISM_03100 | ctaA | ISM_03100 | ISM_16075 | SURF1 family protein. | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | 0.978 |
| ISM_03100 | ctaB | ISM_03100 | ISM_03120 | SURF1 family protein. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.947 |
| ISM_03100 | ctaG | ISM_03100 | ISM_03110 | SURF1 family protein. | Cytochrome C oxidase assembly protein; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I; Belongs to the COX11/CtaG family. | 0.982 |
| ISM_03105 | ISM_03090 | ISM_03105 | ISM_03090 | COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3. | Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | 0.913 |