Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ISM_03655Transcriptional regulator, AraC family protein; COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (343 aa)    
Predicted Functional Partners:
ISM_11935
Transcriptional regulator, AraC family protein; COG2207 AraC-type DNA-binding domain-containing proteins.
  
   0.745
rpoD
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
    
 
 0.562
ISM_03650
COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit.
  
    0.497
ISM_03620
COG1250 3-hydroxyacyl-CoA dehydrogenase.
 
     0.495
ISM_03640
Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
       0.494
ISM_03645
Sulfatase; COG3119 Arylsulfatase A and related enzymes.
       0.494
ISM_03635
Hypothetical protein.
       0.479
ISM_03660
Aminomethyl transferase family protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
       0.473
ISM_03665
COG5598 Trimethylamine:corrinoid methyltransferase; Belongs to the trimethylamine methyltransferase family.
       0.440
ISM_03625
Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
       0.427
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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